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On verifying Bio-PEPA models

Published:29 September 2010Publication History

ABSTRACT

Verifying that a computational model implements the conceptual model of some dynamic biological phenomena is an important yet non-trivial task. In this paper, we discuss a variety of steps that contribute to this verification process, using the Bio-PEPA process algebra as a modelling language and describing the verification steps that are supported by the Bio-PEPA tool. In particular, we elaborate on both static analysis based on the structure of models and dynamic analysis of generated stochastic simulation traces performed using the Traviando trace analyser. We illustrate the approach with a model of a JAK/STAT signalling pathway.

References

  1. }}O. Balci. Quality assessment, verification, and validation of modeling and simulation applications. In Winter Simulation Conference, pages 122--129, 2004. Google ScholarGoogle ScholarDigital LibraryDigital Library
  2. }}Bio-PEPA Home Page. http://www.biopepa.org/.Google ScholarGoogle Scholar
  3. }}C. Chaouiya. Petri net modelling of biological networks. Briefings in Bioinformatics, 8(4):210--219, 2007.Google ScholarGoogle ScholarCross RefCross Ref
  4. }}F. Ciocchetta, A. Duguid, S. Gilmore, M. L. Guerriero, and J. Hillston. The Bio-PEPA tool suite. In Proceedings of QEST'09, pages 309--310, 2009. Google ScholarGoogle ScholarDigital LibraryDigital Library
  5. }}F. Ciocchetta and J. Hillston. Bio-PEPA: a Framework for the Modelling and Analysis of Biological Systems. Theoretical Computer Science, 410(33--34):3065--3084, 2009. Google ScholarGoogle ScholarDigital LibraryDigital Library
  6. }}A. Duguid, S. Gilmore, M. L. Guerriero, J. Hillston, and L. Loewe. Design and Development of Software Tools for Bio-PEPA. In Proc. of WSC'09, pages 956--967. IEEE Press, 2009. Google ScholarGoogle ScholarDigital LibraryDigital Library
  7. }}F. Fages and A. Rizk. On the analysis of numerical data time series in temporal logic. In Computational Methods in Systems Biology '07, pages 48--63. Springer, 2007. LNCS 4695. Google ScholarGoogle ScholarDigital LibraryDigital Library
  8. }}E. Grafahrend-Belau, F. Schreiber, M. Heiner, A. Sackmann, B. H. Junker, S. Grunwald, A. Speer, K. Winder, and I. Koch. Modularization of biochemical networks based on classification of Petri net t-invariants. BMC Bioinformatics, 9(90), 2008.Google ScholarGoogle Scholar
  9. }}M. L. Guerriero. Qualitative and Quantitative Analysis of a Bio-PEPA Model of the Gp130/JAK/STAT Signalling Pathway. Trans. on Computational and Systems Biology XI, pages 90--115, 2009. Google ScholarGoogle ScholarDigital LibraryDigital Library
  10. }}M. Heiner. Understanding network behavior by structured representations of transition invariants. In Algorithmic Bioprocesses. Springer-Verlag, 2009.Google ScholarGoogle Scholar
  11. }}M. Heiner, D. Gilbert, and R. Donaldson. Petri Nets for Systems and Synthetic Biology. In SFM'08, volume 5016 of LNCS, pages 215--264, 2008. Google ScholarGoogle Scholar
  12. }}P. Kemper and C. Tepper. Automated trace analysis of discrete-event system models. IEEE Transactions on Software Engineering, 35(2):195--208, 2009. Google ScholarGoogle ScholarDigital LibraryDigital Library
  13. }}X. Liu and D. Gilbert. BioNessie: A biochemical networks simulation environment. Journal of Cell Research, 2010. To appear.Google ScholarGoogle Scholar
  14. }}J. Martinez and M. Silva. A simple and fast algorithm to obtain all invariants of a generalized Petri net. In Selected Papers from the First and the Second European Workshop on Application and Theory of Petri Nets, pages 301--310. Springer-Verlag, 1982. Google ScholarGoogle Scholar
  15. }}MATLAB. http://www.mathworks.com/.Google ScholarGoogle Scholar
  16. }}MC2(PLTLc) Home Page. http://www.brc.dcs.gla.ac.uk/software/mc2/.Google ScholarGoogle Scholar
  17. }}B. O. Palsson. Systems Biology: Properties of Reconstructed Networks. Cambridge University Press, 2006. Google ScholarGoogle ScholarDigital LibraryDigital Library
  18. }}A. Sackmann, D. Formanowicz, P. Formanowicz, I. Koch, and J. Blazewicz. An analysis of the Petri net based model of the human body iron homeostasis process. Computational Biology and Chemistry, 31(1):1--10, 2007. Google ScholarGoogle ScholarDigital LibraryDigital Library
  19. }}S. Schuster and C. Hilgetag. What information about the conserved-moiety structure of chemical reaction systems can be derived from their stoichiometry? Journal of Physical Chemistry, 99(20):8017--8023, 1995.Google ScholarGoogle ScholarCross RefCross Ref
  20. }}Traviando Home Page. www.cs.wm.edu/~kemper/traviando.html.Google ScholarGoogle Scholar

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          cover image ACM Other conferences
          CMSB '10: Proceedings of the 8th International Conference on Computational Methods in Systems Biology
          September 2010
          119 pages
          ISBN:9781450300681
          DOI:10.1145/1839764
          • Conference Chair:
          • Paola Quaglia

          Copyright © 2010 ACM

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          New York, NY, United States

          Publication History

          • Published: 29 September 2010

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