ABSTRACT
Recent advances in continuous-flow microfluidics have enabled highly integrated lab-on-a-chip biochips. These chips can execute complex biochemical applications precisely and efficiently within a tiny area, but they require a large number of control ports and the corresponding control logic to generate required pressure patterns for flow control, which, consequently, offset their advantages and prevent their wide adoption. In this paper, we propose the first synthesis flow called MiniControl, for continuous-flow microfluidic biochips (CFMBs) under strict constraints for control ports, incorporating high-level synthesis and physical design simultaneously, which has never been considered in previous work. With the maximum number of allowed control ports specified in advance, this synthesis flow generates a biochip architecture with high execution efficiency. Moreover, the overall cost of a CFMB can be reduced and the tradeoff between control logic and execution efficiency of biochemical applications can be evaluated for the first time. Experimental results demonstrate that MiniControl leads to high execution efficiency and low overall platform cost, while satisfying the given control port constraint strictly.
- K. Hu, K. Chakrabarty, and T. Y. Ho, Computer-aided design of microfluidic very largescale integration (mVLSI) biochips, Springer Int. Publishing, 2017. Google ScholarDigital Library
- A. Thiha and F. Ibrahim, "A colorimetric enzyme-linked immunosorbent assay detection platform for a point-of-care dengue detection system on a lab-on-compact-disc," Sensors, 15(5), 11431--11441, 2015.Google ScholarCross Ref
- M. J. Anderson, C. L. Hansen, and S. R. Quake, "Phase knowledge enables rational screens for protein crystallization," PNAS, 103(45), 16746--16751, 2006.Google ScholarCross Ref
- Research & Market, "Microfluidics market by application, component and material - global forecast to 2023," Online available: https://www.researchandmarkets.com/.Google Scholar
- T. M. Squires and S. R. Quake, "Microfluidics: fluid physics at the nanoliter scale" Revi. Modern Physi., 77(3), 977--977, 2005.Google ScholarCross Ref
- I. E. Araci, S. R. Quake, "Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves," Lab Chip, 12(16), 2803--2806, 2012.Google ScholarCross Ref
- Microfluidics Design Rules. Online available:http://www.stanford.edu/group/foundry/Basic%20Design%20Rules.html.Google Scholar
- K. Hu, T. A. Dinh, T. Y. Ho, and K. Chakrabarty, "Control-layer routing and control-pin minimization for flow-based microfluidic biochips," IEEE Trans. on CAD, 36(1), 55--68, 2017. Google ScholarDigital Library
- D. S. Kong, T. A. Thorsen, J. Babb et al., "Open-source, community-driven microfluidics with metafluidics," Nat. Biotechnol., 1612--1619, 2017.Google Scholar
- W. H. Minhass, P. Pop, J. Madsen, and T. Y. Ho, "Control synthesis for the flow-based microfluidic large-scale integration biochips," Proc. of ASP-DAC, 205--212, 2013.Google Scholar
- Q. Wang, S. Zuo, H. Yao, T.-Y. Ho, B. Li, U. Schlichtmann, and Y. C., "Hamming-distance-based valve-switching optimization for control-layer multiplexing in flow-based microfluidic biochips," Proc. of ASP-DAC, 524--529, 2017.Google Scholar
- Y. Zhu, B. Li, T.-Y. Ho, Q. Wang, H. Yao, R. Wille, and U. Schlichtmann, "Multi-channel and fault-tolerant control multiplexing for flow-based microfluidic biochips," Proc. of ICCAD, 123:1--123:8, 2018. Google ScholarDigital Library
- Z. S. Chen, X. Huang, W. Z. Guo et al., "Physical Synthesis of Flow-Based Microfluidic Biochips Considering Distributed Channel Storage", to appear in Proc. of DATE, 2019.Google Scholar
- G. L. Gros and J. Yellen, Graph Theory and Its Applications, Chapman and Hall/CRC, 2005. Google ScholarDigital Library
- M. R. Garey, and D. S. Johnson, Computers and intractability guide to the theory of NP-completeness, New York: Freeman, 2002.Google Scholar
- J. Kennedy and R. C. Eberhart, "Particle swarm optimization", Proc. of IJCNN, 1942-C1948, 1995.Google ScholarCross Ref
- G. D. Micheli, Synthesis and optimization of digital circuits, McGraw-Hill Higher Education, 1994. Google ScholarDigital Library
- S. Kirkpatrick, C. D. Gelatt, and M. P. Vecchi, "Optimization by simulated annealing," Science, 220(4598), 671--680, 1983.Google ScholarCross Ref
- P. E. Hart, N.J. Nilsson, and B. Raphael, "A formal basis for the heuristic determination of minimum cost paths," IEEE Trans. on Syst. Sci. Cyber., 4(2), 100--107, 1968.Google ScholarCross Ref
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