ABSTRACT
To support basic sleep research, several automated sleep stage scoring methods for mice have been proposed. Although these methods can score mice sleep stages accurately based on their electroencephalogram (EEG) and electromyogram (EMG) signals, they are fragile against noise, especially in EEG signals. The simplest solution is to reduce or eliminate noise before scoring. However, a method for reducing noise in biological signals does not exist. Because EEG signals contain many types of noise, predicting all of them is difficult, which inhibits the use of hand-engineered methods such as frequency filters. Additionally, noise reduction methods with deep learning models are not applicable as they require records of noise, and the noise considered here cannot be measured separately from biological signals. In this study, we address this problem using adversarial training, which is a method for deep learning models that does not require noise records as training samples. We propose a new noise-reduction model called "NR-GAN." Its training process requires a set of noisy signals and a set of clear signals. Since these sets can be measured independently, NR-GAN can reduce noise in mice EEG signals.
- Genshiro A Sunagawa, Hiroyoshi Séi, Shigeki Shimba, Yoshihiro Urade, and Hiroki R Ueda. Faster: an unsupervised fully automated sleep staging method for mice. Genes to Cells, Vol. 18, No. 6, pp. 502--518, 2013.Google Scholar
- Yuta Suzuki, Makito Sato, Hiroaki Shiokawa, Masashi Yanagisawa, and Hiroyuki Kitagawa. Masc: Automatic sleep stage classification based on brain and myoelectric signals. In Data Engineering (ICDE), 2017 IEEE 33rd International Conference on, pp. 1489--1496, 2017.Google ScholarCross Ref
- Akara Supratak, Hao Dong, Chao Wu, and Yike Guo. Deepsleepnet: A model for automatic sleep stage scoring based on raw single-channel eeg. IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 25, No. 11, pp. 1998--2008, 2017.Google ScholarCross Ref
- Vance Gao, Fred Turek, and Martha Vitaterna. Multiple classifier systems for automatic sleep scoring in mice. Journal of neuroscience methods, Vol. 264, pp. 33--39, 2016.Google Scholar
- Farid Yaghouby, Bruce FO 'Hara, Sridhar Sunderam. Unsupervised estimation of mouse sleep scores and dynamics using a graphical model of electrophysiological measurements. International journal of neural systems, Vol. 26, No. 04, p. 1650017, 2016.Google Scholar
- Đorđe Miladinovicć, Christine Muheim, Stefan Bauer, Andrea Spinnler, Daniela Noain, Mojtaba Bandarabadi, Benjamin Gallusser, Gabriel Krummenacher, Christian Baumann, Antoine Adamantidis, et al. Spindle: End-to-end learning from eeg/emg to extrapolate animal sleep scoring across experimental settings, labs and species. PLoS computational biology, Vol. 15, No. 4, p. e1006968, 2019.Google Scholar
- Yong Xu, Jun Du, Li-Rong Dai, and Chin-Hui Lee. A regression approach to speech enhancement based on deep neural networks. IEEE/ACM Transactions on Audio, Speech and Language Processing (TASLP), Vol. 23, No. 1, pp. 7--19, 2015.Google Scholar
- DanielMichelsantiandZheng-HuaTan.Conditional generative adversarial networks for speech enhancement and noise-robust speaker verification. arXiv preprint arXiv:1709.01703, 2017.Google Scholar
- Jürgen Schmidhuber. Deep learning in neural networks: An overview. Neural networks, Vol. 61, pp. 85--117, 2015.Google Scholar
- Ian Goodfellow, Jean Pouget-Abadie, Mehdi Mirza, Bing Xu, David Warde-Farley, Sherjil Ozair, Aaron Courville, and Yoshua Bengio. Generative adversarial nets. In Advances in neural information processing systems, pp. 2672--2680, 2014.Google ScholarDigital Library
- Ashish Shrivastava, Tomas Pfister, Oncel Tuzel, Joshua Susskind, Wenda Wang, and Russell Webb. Learning from simulated and unsupervised images through adversarial training. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2107--2116, 2017.Google ScholarCross Ref
- Kaiming He, Xiangyu Zhang, Shaoqing Ren, and Jian Sun. Deep residual learning for image recognition. In Proceedings of the IEEE conference on computer vision and pattern recognition, pp. 770--778, 2016.Google ScholarCross Ref
- Jun-Yan Zhu, Taesung Park, Phillip Isola, and Alexei A Efros. Unpaired image-to-image translation using cycle-consistent adversarial networks. arXiv preprint arXiv:1703.10593, 2017.Google Scholar
- Taeksoo Kim, Moonsu Cha, Hyunsoo Kim, Jungkwon Lee, and Jiwon Kim. Learning to discover cross-domain relations with generative adversarial networks. arXiv preprint arXiv:1703.05192, 2017.Google Scholar
Index Terms
- NR-GAN: Noise Reduction GAN for Mice Electroencephalogram Signals
Recommendations
Electroencephalogram Signals Denoising using Various Mother Wavelet Functions: A Comparative Analysis
ICISPC 2017: Proceedings of the International Conference on Imaging, Signal Processing and CommunicationIn this paper, various mother wavelet functions are proposed for ElectroEncephaloGram (EEG) signal denoising problem. EEG is a graphical measuring of the brain electrical activity which is recording from the scalp. It represents the voltage fluctuations ...
Robust Volterra Filter Design for Enhancement of Electroencephalogram Signal Processing
Electroencephalogram (EEG) recordings often experience interference by different kinds of noise, including white, muscle, and baseline, severely limiting its utility. The recent research has demonstrated that discrete-time Volterra models can be ...
A periodic spatio-spectral filter for event-related potentials
With respect to single trial detection of event-related potentials (ERPs), spatial and spectral filters are two of the most commonly used pre-processing techniques for signal enhancement. Spatial filters reduce the dimensionality of the data while ...
Comments