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NR-GAN: Noise Reduction GAN for Mice Electroencephalogram Signals

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Published:15 January 2020Publication History

ABSTRACT

To support basic sleep research, several automated sleep stage scoring methods for mice have been proposed. Although these methods can score mice sleep stages accurately based on their electroencephalogram (EEG) and electromyogram (EMG) signals, they are fragile against noise, especially in EEG signals. The simplest solution is to reduce or eliminate noise before scoring. However, a method for reducing noise in biological signals does not exist. Because EEG signals contain many types of noise, predicting all of them is difficult, which inhibits the use of hand-engineered methods such as frequency filters. Additionally, noise reduction methods with deep learning models are not applicable as they require records of noise, and the noise considered here cannot be measured separately from biological signals. In this study, we address this problem using adversarial training, which is a method for deep learning models that does not require noise records as training samples. We propose a new noise-reduction model called "NR-GAN." Its training process requires a set of noisy signals and a set of clear signals. Since these sets can be measured independently, NR-GAN can reduce noise in mice EEG signals.

References

  1. Genshiro A Sunagawa, Hiroyoshi Séi, Shigeki Shimba, Yoshihiro Urade, and Hiroki R Ueda. Faster: an unsupervised fully automated sleep staging method for mice. Genes to Cells, Vol. 18, No. 6, pp. 502--518, 2013.Google ScholarGoogle Scholar
  2. Yuta Suzuki, Makito Sato, Hiroaki Shiokawa, Masashi Yanagisawa, and Hiroyuki Kitagawa. Masc: Automatic sleep stage classification based on brain and myoelectric signals. In Data Engineering (ICDE), 2017 IEEE 33rd International Conference on, pp. 1489--1496, 2017.Google ScholarGoogle ScholarCross RefCross Ref
  3. Akara Supratak, Hao Dong, Chao Wu, and Yike Guo. Deepsleepnet: A model for automatic sleep stage scoring based on raw single-channel eeg. IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 25, No. 11, pp. 1998--2008, 2017.Google ScholarGoogle ScholarCross RefCross Ref
  4. Vance Gao, Fred Turek, and Martha Vitaterna. Multiple classifier systems for automatic sleep scoring in mice. Journal of neuroscience methods, Vol. 264, pp. 33--39, 2016.Google ScholarGoogle Scholar
  5. Farid Yaghouby, Bruce FO 'Hara, Sridhar Sunderam. Unsupervised estimation of mouse sleep scores and dynamics using a graphical model of electrophysiological measurements. International journal of neural systems, Vol. 26, No. 04, p. 1650017, 2016.Google ScholarGoogle Scholar
  6. Đorđe Miladinovicć, Christine Muheim, Stefan Bauer, Andrea Spinnler, Daniela Noain, Mojtaba Bandarabadi, Benjamin Gallusser, Gabriel Krummenacher, Christian Baumann, Antoine Adamantidis, et al. Spindle: End-to-end learning from eeg/emg to extrapolate animal sleep scoring across experimental settings, labs and species. PLoS computational biology, Vol. 15, No. 4, p. e1006968, 2019.Google ScholarGoogle Scholar
  7. Yong Xu, Jun Du, Li-Rong Dai, and Chin-Hui Lee. A regression approach to speech enhancement based on deep neural networks. IEEE/ACM Transactions on Audio, Speech and Language Processing (TASLP), Vol. 23, No. 1, pp. 7--19, 2015.Google ScholarGoogle Scholar
  8. DanielMichelsantiandZheng-HuaTan.Conditional generative adversarial networks for speech enhancement and noise-robust speaker verification. arXiv preprint arXiv:1709.01703, 2017.Google ScholarGoogle Scholar
  9. Jürgen Schmidhuber. Deep learning in neural networks: An overview. Neural networks, Vol. 61, pp. 85--117, 2015.Google ScholarGoogle Scholar
  10. Ian Goodfellow, Jean Pouget-Abadie, Mehdi Mirza, Bing Xu, David Warde-Farley, Sherjil Ozair, Aaron Courville, and Yoshua Bengio. Generative adversarial nets. In Advances in neural information processing systems, pp. 2672--2680, 2014.Google ScholarGoogle ScholarDigital LibraryDigital Library
  11. Ashish Shrivastava, Tomas Pfister, Oncel Tuzel, Joshua Susskind, Wenda Wang, and Russell Webb. Learning from simulated and unsupervised images through adversarial training. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2107--2116, 2017.Google ScholarGoogle ScholarCross RefCross Ref
  12. Kaiming He, Xiangyu Zhang, Shaoqing Ren, and Jian Sun. Deep residual learning for image recognition. In Proceedings of the IEEE conference on computer vision and pattern recognition, pp. 770--778, 2016.Google ScholarGoogle ScholarCross RefCross Ref
  13. Jun-Yan Zhu, Taesung Park, Phillip Isola, and Alexei A Efros. Unpaired image-to-image translation using cycle-consistent adversarial networks. arXiv preprint arXiv:1703.10593, 2017.Google ScholarGoogle Scholar
  14. Taeksoo Kim, Moonsu Cha, Hyunsoo Kim, Jungkwon Lee, and Jiwon Kim. Learning to discover cross-domain relations with generative adversarial networks. arXiv preprint arXiv:1703.05192, 2017.Google ScholarGoogle Scholar

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      cover image ACM Other conferences
      ICBSP '19: Proceedings of the 2019 4th International Conference on Biomedical Imaging, Signal Processing
      October 2019
      108 pages
      ISBN:9781450372954
      DOI:10.1145/3366174

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      Publication History

      • Published: 15 January 2020

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