Sweeter But Deadlier: Decoupling Size, Charge and Capping Effects in Carbohydrate Coated Bactericidal Silver Nanoparticles
Silver nanoparticles are widely used due to their biomedical-antibacterial applications. At the same time, the stabilization of these nanoparticles is challenging and may be made using polymeric carbohydrates, based on the practice of avoiding toxic chemicals and undesirable residues.
In this study, we synthesized silver nanoparticles (AgNPs) which were stabilized by carbohydrates (potato starch and chitosan) and characterized by UV-Vis spectroscopy, zeta potential and transmission electron microscopy techniques. Bactericidal efficiency of AgNPs capped with different carbohydrates
was tested demonstrating that the synthesized materials were able to inhibit the growth of two clinical/medical relevant bacteria strains (Escherichia coli and Staphylococcus aureus). AgNPs stabilized by chitosan presented enhanced bactericidal activity if compared to the ones
synthesized in presence of potato starch. This difference is mainly attributed to the known antibacterial properties of chitosan associated to overall positive charge of the nanoparticles capped by this polymer. Those nanoparticles obtained in presence of starch presented minor bactericidal
effects since the starch-capping agent is not able to contribute to the avoidance of bacteria growth and confers a quasi-neutral charge to the nanoparticle.
Keywords: BACTERICIDAL PROPERTIES; CARBOHYDRATE STABILIZATION; CHITOSAN; SILVER NANOPARTICLES; STARCH
Document Type: Research Article
Publication date: 01 September 2013
- Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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