Brief ReportSubjective Memory Complaints With and Without Objective Memory Impairment: Relationship With Risk Factors for Dementia
Section snippets
METHODS
Community-dwelling women age 70 years or over, living in the metropolitan area of Perth, Western Australia, were recruited via advertisement in various media to participate as volunteers in a longitudinal research project investigating mental health and the quality of life of older women and its association with estrogen replacement. This study describes cross-sectional information obtained at their time of recruitment into that study. The following exclusion criteria applied: 1) Mini-Mental
RESULTS
A total of 264 women were included in the study; 106 did not report poor memory and had WL Delayed Recall scores ≥2; they were grouped under the heading of healthy-comparison group (HCG).
A group of 121 women complained of memory problems but did not display objective memory impairment, as defined by a score of 0 or 1 on the delayed component of the WL (SMC); 37 women (14% of the total sample) displayed objective memory impairment, with 28 of them also reporting subjective memory impairment
DISCUSSION
The results of this study showed that women with MCI have significantly higher plasma homocysteine levels than healthy-comparison subjects. We were unable to demonstrate a clear association between MCI and APOE ε4 genotyping, possibly because of insufficient study power. In contrast, participants with SMC did not differ from women in the healthy-comparison group in relation to their total plasma homocysteine or APOE genotype. They did differ, however, on BDI and BAI scores, as well as quality
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Subjective Memory Complaints are Associated with Incident Dementia in Cognitively Intact Older People, but Not in Those with Cognitive Impairment: A 24-Month Prospective Cohort Study
2017, American Journal of Geriatric PsychiatryCitation Excerpt :In the present study, the risk of incident dementia was not significantly different in cognitively impaired participants with or without SMCs. In a previous study by Lautenschlager et al., the presence of cognitive impairment was a strong risk factor for dementia among older people, regardless of the association with SMCs.32 These results were supported by our findings.
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2015, Artificial Intelligence in MedicinePredicting cognitive, functional, and diagnostic change over 4 years using baseline subjective cognitive complaints in the Sydney Memory and Ageing Study
2015, American Journal of Geriatric PsychiatryCitation Excerpt :However, investigation of the associations between SCCs and objective cognitive performance,7–13 MCI,9,11,14 and future dementia9,15 in cross-sectional and longitudinal studies has yielded mixed results.16 Strong associations have consistently been reported between SCCs and depression,8,10,16,17 anxiety,10,16,17 and personality traits,18 including neuroticism, openness, and conscientiousness.16 Differences between studies might be explained by definitional and methodologic issues.
We thank Kellie Cassidy, Dr. Ria Kotynia, Lee Barclay, Felicity Roche, Dr. Brett Coulson, Dr. Steve Fenner, Dr. Helen McGowan, and Tricia Knox for their assistance with data collection and management. The investigators gratefully acknowledge the generous contribution of the women who took part in this study.
This project was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC).