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Some Developments on the International Index of Erectile Function (IIEF)

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Abstract

This manuscript covers two complementary topics. For both topics, data from clinical studies and control samples were used. The first topic provides an overview of the development and validation of the International Index of Erectile Function (IIEF), a 15-item questionnaire, for male erectile and sexual function. A principal components analysis revealed five factors (erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction). The IIEF demonstrated reliability, validity, and sensitivity and specificity with regard to treatment effect. The second topic presents, among men who reported having had sexual intercourse, the methodology and results on the evaluation of the erectile function (EF) domain of the IIEF, which has a range of scores from 6–30 for these men, as a diagnostic tool to help discriminate between men with and without erectile dysfunction (ED). For a prevalence rate of ED equal to 0.5 in a clinical population, the Classification and Regression Trees program gave a cutoff score of 25: men with EF scores of 25 or less were retrospectively classified as having ED, while those with scores above 25 were classified as not having ED (sensitivity = 0.97, specificity = 0.88). The IIEF has been developed and validated as a scale that is reliable, brief, self-administered, and psychometrically sound. Its EF domain showed desirable diagnostic properties. More research is encouraged in this area.

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Authors and Affiliations

  1. Department of Clinical Research, Biometrics, Eastern Point Road, Groton, CT, 06340, USA

    Joseph C. Cappelleri PhD, MPH (Associate Director)

  2. Center for Sex and Marital Health, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA

    Raymond C. Rosen PhD (Professor of Psychiatry)

  3. Pfizer Central Research, Biometrics, Sandwich, UK

    Michael D. Smith PhD (Lead Statistician)

  4. Clinical Development, Pfizer Central Research, Sandwich, UK

    Frances Quirk PhD (Local Clinical Team Leader) & Murray C. Maytom MD (Clinical Project Manager)

  5. Outcomes Research, Pfizer Pharmaceuticals Group, New York, New York, USA

    Avanish Mishra PhD (Senior Manager)

  6. Viagra, Pfizer Central Research, Sandwich, UK

    Ian H. Osterloh MD (Global Candidate Team Leader)

Authors
  1. Joseph C. Cappelleri PhD, MPH
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  2. Raymond C. Rosen PhD
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  3. Michael D. Smith PhD
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  4. Frances Quirk PhD
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  5. Murray C. Maytom MD
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  6. Avanish Mishra PhD
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  7. Ian H. Osterloh MD
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Correspondence to Joseph C. Cappelleri PhD, MPH.

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Cappelleri, J.C., Rosen, R.C., Smith, M.D. et al. Some Developments on the International Index of Erectile Function (IIEF). Ther Innov Regul Sci 33, 179–190 (1999). https://doi.org/10.1177/009286159903300122

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  • DOI: https://doi.org/10.1177/009286159903300122

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