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In Estimated Good Prognosis Patients Could Unexpected “Hyporesponse” to Controlled Ovarian Stimulation be Related to Genetic Polymorphisms of FSH Receptor?

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Abstract

It has been reported that 10% to 15% of young normogonadotrophic women show suboptimal response to standard gonadotropin-releasing hormone—a long protocol. These patients require higher doses of exogenous follicle-stimulating hormone (FSH). This phenomenon could be associated with genetic characteristics. In this study, FSH receptor polymorphism was retrospectively evaluated in 42 normoresponder young women undergoing an in vitro fertilization/intracytoplasmic sperm injection cycle; patients were stratified according to recombinant human FSH (r-hFSH) consumption. We selected 17 normoresponder young patients who required a cumulative dose of recombinant FSH (rFSH) >2500 UI (group A). A control group was randomly selected among patients who required a cumulative dose of rFSH <2500 UI (group B). Follicle-stimulating hormone receptor (FSH-R) 307Ala and 680Ser variants were analyzed in all our patients. Our results show that the mean number of rFSH vials (36.3 ± 7.5 vs 28.6 ± 4.5, P = .0001) and days of stimulation (12.7 ± 2.4 vs 10.8 ± 2.8, P = .03) were significantly lower in group B, whereas the number of oocytes retrieved (7.1 ± 1.5 vs 9.6 ± 2.4; P = .0005) and the average number of embryos transferred (2.1 ± 0.7 vs 2.7 ± 0.4; P = .001) were significantly lower in group A. Estradiol serum levels on the human chorionic gonadotrophin day were significantly lower in group A (997.8 ± 384.9 pg/mL vs 1749.1 ± 644.4; P = .0001). The incidence of the Ser/Ser genotype was higher in patients with higher r-hFSH consumption (group A; P = .02). Based on our results, we hypothesize an association between the FSH-R polymorphisms and a “hyporesponse” to exogenous FSH.

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Authors and Affiliations

  1. Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples “Federico II”, Naples, Italy

    Carlo Alviggi MD, PhD, Alessandro Conforti MD, Ida Strina MD, Tiziana Pagano MD, Pasquale De Rosa MD, Floriana Carbone MD & Giuseppe De Placido MD

  2. Outpatient Fertility Unit, Second University of Naples, Naples, Italy

    Francesca Caprio MD & Nicola Colacurci MD

  3. Department of Woman and Child Health, University of Padua, Padua, Italy

    Salvatore Gizzo MD & Marco Noventa MD

Authors
  1. Carlo Alviggi MD, PhD
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  2. Alessandro Conforti MD
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  3. Francesca Caprio MD
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  4. Salvatore Gizzo MD
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  5. Marco Noventa MD
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  6. Ida Strina MD
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  7. Tiziana Pagano MD
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  8. Pasquale De Rosa MD
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  9. Floriana Carbone MD
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  10. Nicola Colacurci MD
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  11. Giuseppe De Placido MD
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Correspondence to Salvatore Gizzo MD.

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Alviggi, C., Conforti, A., Caprio, F. et al. In Estimated Good Prognosis Patients Could Unexpected “Hyporesponse” to Controlled Ovarian Stimulation be Related to Genetic Polymorphisms of FSH Receptor?. Reprod. Sci. 23, 1103–1108 (2016). https://doi.org/10.1177/1933719116630419

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