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Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis

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Abstract

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17–20, 2017, in Vancouver, British Columbia, Canada.

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References

  1. Rogers PA, D’Hooghe TM, Fazleabas A, et al. Priorities for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2009;16(4):335–346.

    Article  PubMed  Google Scholar 

  2. Rogers PA, D’Hooghe TM, Fazleabas A, et al. Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis in Montpellier, France. Reprod Sci. 2013;20(5):483–499.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Becker CM, Laufer MR, Stratton P, et al. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research. Fertil Steril. 2014;102(5):1213–1222.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Vitonis AF, Vincent K, Rahmioglu N, et al. World Endometrio-sis Research Foundation Endometriosis Phenome and biobanking harmonization project: II. Clinical and covariate phenotype data collection in endometriosis research. Fertil Steril. 2014;102(5):1223–1232.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98(3):511–519.

    Article  CAS  PubMed  Google Scholar 

  6. Hickey M, Ballard K, Farquhar C. Endometriosis. BMJ. 2014; 348:1–9.

    Article  Google Scholar 

  7. Simoens S, Dunselman G, Dirksen C, et al. The burden of endo-metriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292–1299.

    Article  PubMed  Google Scholar 

  8. Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endo-metriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373. e368.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Culley L, Law C, Hudson N, et al. The social and psychological impact of endometriosis on women’s lives: a critical narrative review. Hum Reprod Update. 2013;19(6):625–639.

    Article  PubMed  Google Scholar 

  10. Vercellini P, Barbara G, Abbiati A, Somigliana E, Vigano P, Fedele L. Repetitive surgery for recurrent symptomatic endome-triosis: what to do? Euro J Obstet Gynecol Reprod Biol. 2009;146(1):15–21.

    Article  Google Scholar 

  11. Rahmioglu N, Fassbender A, Vitonis AF, et al. World Endome-triosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril. 2014;102(5):1233–1243.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Fassbender A, Rahmioglu N, Vitonis AF, et al. World Endome-triosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril. 2014;102(5):1244–1253.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Shah DK, Missmer SA. Scientific investigation of endometriosis among adolescents. J Pediatr Adolesc Gynecol. 2011;24(suppl 5):S18–S19.

    Article  PubMed  Google Scholar 

  14. Reis FM, Luisi S, Abrao MS, et al. Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Hum Reprod. 2012;27(5):1445–1450.

    Article  CAS  PubMed  Google Scholar 

  15. Zeng C, Xu JN, Zhou Y, Zhou YF, Zhu SN, Xue Q. Reproductive performance after surgery for endometriosis: predictive value of the revised American Fertility Society classification and the endometriosis fertility index. Gynecol Obstet Invest. 2014;77(3):180–185.

    Article  PubMed  Google Scholar 

  16. Savaris RF, Nichols CR, Lessey BA. Endometriosis and the enigmatic question of progression. JEPPD. 2014;6(3):121–126.

    Google Scholar 

  17. Marziali M, Venza M, Lazzaro S, Lazzaro A, Micossi C, Stolfi VM. Gluten-free diet: a new strategy for management of painful endometriosis related symptoms? Minerva Chir. 2012;67(6):499–504.

    CAS  PubMed  Google Scholar 

  18. Durak Y, Kokcu A, Kefeli M, Bildircin D, Celik H, Alper T. Effect of vitamin C on the growth of experimentally induced endometriotic cysts. J Obstet Gynaecol Res. 2013;39(7):1253–1258.

    Article  PubMed  CAS  Google Scholar 

  19. Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol. 2013;177(5):420–430.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Darling AM, Chavarro JE, Malspeis S, Harris HR, Missmer SA. A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis. J Endometr. 2013;5(1):17–26.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Herington JL, Glore DR, Lucas JA, Osteen KG, Bruner-Tran KL. Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model. Fertil Steril. 2013;99(2):543–550.

    Article  CAS  PubMed  Google Scholar 

  22. Rudzitis-Auth J, Korbel C, Scheuer C, Menger MD, Laschke MW. Xanthohumol inhibits growth and vascularization of developing endometriotic lesions. Hum Reprod. 2012;27(6):1735–1744.

    Article  CAS  PubMed  Google Scholar 

  23. Savaris AL, do Amaral VF. Nutrient intake, anthropometric data and correlations with the systemic antioxidant capacity of women with pelvic endometriosis. Eur J Obstet Gynecol Reprod Biol. 2011;158(2):314–318.

    Article  CAS  PubMed  Google Scholar 

  24. Lafay Pillet MC, Schneider A, Borghese B, et al. Deep infiltrating endometriosis is associated with markedly lower body mass index: a 476 case-control study. Hum Reprod. 2012;27(1):265–272.

    Article  PubMed  Google Scholar 

  25. Shah DK, Correia KF, Vitonis AF, Missmer SA. Body size and endometriosis: results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort. Hum Reprod. 2013;28(7):1783–1792.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Upson K, De Roos AJ, Thompson ML, et al. Organochlorine pesticides and risk of endometriosis: findings from a population-based case-control study. Environ Health Perspect. 2013;121(11-12):1319–1324.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Wolff EF, Sun L, Hediger ML, et al. In utero exposures and endometriosis: the Endometriosis, Natural History, Disease, Outcome (ENDO) Study. Fertil Steril. 2013;99(3):790–795.

    Article  CAS  PubMed  Google Scholar 

  28. Kvaskoff M, Bijon A, Clavel-Chapelon F, Mesrine S, Boutron-Ruault MC. Childhood and adolescent exposures and the risk of endometriosis. Epidemiology. 2013;24(2):261–269.

    Article  PubMed  Google Scholar 

  29. Montgomery GW, Nyholt DR, Zhao ZZ, et al. The search for genes contributing to endometriosis risk. Hum Reprod Update. 2008;14(5):447–457.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Rahmioglu N, Nyholt DR, Morris AP, Missmer SA, Montgomery GW, Zondervan KT. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update. 2014;20(5):702–716.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Albertsen HM, Chettier R, Farrington P, Ward K. Genome-wide association study link novel loci to endometriosis. PLoS One. 2013;8(3):e58257.

    Google Scholar 

  32. Pagliardini L, Gentilini D, Vigano P, et al. An Italian association study and meta-analysis with previous GWAS confirm WNT4, CDKN2BAS and FN1 as the first identified susceptibility loci for endometriosis. J Med Genet. 2013;50(1):43–46.

    Article  CAS  PubMed  Google Scholar 

  33. Sundqvist J, Xu H, Vodolazkaia A, et al. Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population. Hum Reprod. 2013;28(3):835–839.

    Article  CAS  PubMed  Google Scholar 

  34. Nyholt DR, Low SK, Anderson CA, et al. Genome-wide association meta-analysis identifies new endometriosis risk loci. Nat Genet. 2012;44(12):1355–1359.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Hata Y, Nakaoka H, Yoshihara K, et al. A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population. J Hum Genet. 2013;58(8):517–520.

    Article  CAS  PubMed  Google Scholar 

  36. Sapkota Y, Low SK, Attia J, et al. Association between endo-metriosis and the interleukin 1A (IL1A) locus. Hum Reprod. 2015;30(1):239–248.

    Article  CAS  PubMed  Google Scholar 

  37. Rahmioglu N, Macgregor S, Drong AW, et al. Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. Hum Mol Genet. 2015;24(4):1185–1199.

    Article  CAS  PubMed  Google Scholar 

  38. Lu Y, Cuellar-Partida G, Painter JN, et al. Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. Hum Mol Genet. 2015;24(20):5955–5964.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Lee SH, Harold D, Nyholt DR, et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer’s disease, multiple sclerosis and endometriosis. Hum Mol Genet. 2013;22(4):832–841.

    Article  CAS  PubMed  Google Scholar 

  40. Montgomery GW, Zondervan KT, Nyholt DR. The future for genetic studies in reproduction. Mol Hum Reprod. 2014;20(1):1–14.

    Article  CAS  PubMed  Google Scholar 

  41. Edwards SL, Beesley J, French JD, Dunning AM. Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet. 2013;93(5):779–797.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Wu Y, Halverson G, Basir Z, Strawn E, Yan P, Guo SW. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol. 2005;193(2):371–380.

    Article  CAS  PubMed  Google Scholar 

  43. Wu Y, Strawn E, Basir Z, Halverson G, Guo SW. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. Epigenetics. 2006;1(2):106–111.

    Article  PubMed  Google Scholar 

  44. Wu Y, Strawn E, Basir Z, Halverson G, Guo SW. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometrio-sis. Fertil Steril. 2007;87(1):24–32.

    Article  CAS  PubMed  Google Scholar 

  45. Bulun SE, Cheng YH, Pavone ME, et al. 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. Semin Reprod Med. 2010;28(1):44–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Smuc T, Hevir N, Ribic-Pucelj M, Husen B, Thole H, Rizner TL. Disturbed estrogen and progesterone action in ovarian endome-triosis. Mol Cell Endocrinol. 2009;301(1-2):59–64.

    Article  CAS  PubMed  Google Scholar 

  47. Brosens I, Brosens JJ, Benagiano G. The eutopic endometrium in endometriosis: are the changes of clinical significance? Reprod Biomed Online. 2012;24(5):496–502.

    Article  PubMed  Google Scholar 

  48. Cakmak H, Taylor HS. Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions. Semin Reprod Med. 2010;28(1):69–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Dyson MT, Roqueiro D, Monsivais D, et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis. PLoS Genet. 2014;10(3): e1004158.

    Google Scholar 

  50. Saare M, Modhukur V, Suhorutshenko M, et al. The influence of menstrual cycle and endometriosis on endometrial methylome. Clin Epigenetics. 2016;8:2.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  51. Shah S, Bonder MJ, Marioni RE, et al. Improving phenotypic prediction by combining genetic and epigenetic associations. Am J Hum Genet. 2015;97(1):75–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Mai A, Altucci L. Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead. Int J Biochem Cell Biol. 2009;41(1):199–213.

    Article  CAS  PubMed  Google Scholar 

  53. Chen H, Hardy TM, Tollefsbol TO. Epigenomics of ovarian cancer and its chemoprevention. Front Genet. 2011;2:67.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Hagelkruys A, Sawicka A, Rennmayr M, Seiser C. The biology of HDAC in cancer: the nuclear and epigenetic components. Handb Exp Pharmacol. 2011;206:13–37.

    Article  CAS  PubMed  Google Scholar 

  55. Crisanti MC, Wallace AF, Kapoor V, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009;8(8):2221–2231.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Colon-Diaz M, Baez-Vega P, Garcia M, et al. HDAC1 and HDAC2 are differentially expressed in endometriosis. Reprod Sci. 2012;19(5):483–492.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Samartzis EP, Noske A, Samartzis N, Fink D, Imesch P. The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in endometriosis. Reprod Sci. 2013;20(12):1416–1422.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Monteiro JB, Colon-Diaz M, Garcia M, et al. Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. Reprod Sci. 2014;21(3):305–318.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  59. Xiaomeng X, Ming Z, Jiezhi M, Xiaoling F. Aberrant histone acetylation and methylation levels in woman with endometrio-sis. Arch Gynecol Obstet. 2013;287(3):487–494.

    Article  PubMed  CAS  Google Scholar 

  60. Spannhoff A, Hauser AT, Heinke R, Sippl W, Jung M. The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors. ChemMedChem. 2009;4(10):1568–1582.

    Article  CAS  PubMed  Google Scholar 

  61. Piekarz RL, Bates SE. Epigenetic modifiers: basic understanding and clinical development. Clin Cancer Res. 2009;15(12):3918–3926.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Kawano Y, Nasu K, Li H, et al. Application of the histone deacetylase inhibitors for the treatment of endometriosis: his-tone modifications as pathogenesis and novel therapeutic target. Hum Reprod. 2011;26(9):2486–2498.

    Article  CAS  PubMed  Google Scholar 

  63. Wu Y, Guo SW. Inhibition of proliferation of endometrial stro-mal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. Gynecol Obstet Invest. 2006;62(4):193–205.

    Article  CAS  PubMed  Google Scholar 

  64. Matsuzaki S, Darcha C. Epithelial to mesenchymal transitionlike and mesenchymal to epithelial transition-like processes might be involved in the pathogenesis of pelvic endometriosis. Hum Reprod. 2012;27(3):712–721.

    Article  CAS  PubMed  Google Scholar 

  65. Cousins FL, Murray A, Esnal A, Gibson DA, Critchley HO, Saunders PT. Evidence from a mouse model that epithelial cell migration and mesenchymal-epithelial transition contribute to rapid restoration of uterine tissue integrity during menstruation. PLoS One. 2014;9(1):e86378.

    Google Scholar 

  66. Proestling K, Birner P, Gamperl S, et al. Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis. Reprod Biol Endocrinol. 2015;13:75.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  67. Nakamura M, Ono YJ, Kanemura M, et al. Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum. Gynecol Oncol. 2015;139(2):345–354.

    Article  CAS  PubMed  Google Scholar 

  68. Greaves E, Cousins FL, Murray A, et al. A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium. Am J Pathol. 2014;184(7):1930–1939.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41(1):49–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Thiruchelvam U, Dransfield I, Saunders PT, Critchley HO. The importance of the macrophage within the human endometrium. J Leukoc Biol. 2013;93(2):217–225.

    Article  CAS  PubMed  Google Scholar 

  71. Guilliams M, Ginhoux F, Jakubzick C, et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol. 2014;14(8):571–578.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Kirchhoff D, Kaulfuss S, Fuhrmann U, Maurer M, Zollner TM. Mast cells in endometriosis: guilty or innocent bystanders? Expert Opin Ther Targets. 2012;16(3):237–241.

    Article  CAS  PubMed  Google Scholar 

  73. Matsuzaki S, Canis M, Darcha C, Fukaya T, Yajima A, Bruhat MA. Increased mast cell density in peritoneal endometriosis compared with eutopic endometrium with endometriosis. Am J Reprod Immunol. 1998;40(4):291–294.

    Article  CAS  PubMed  Google Scholar 

  74. Greaves E, Grieve K, Horne AW, Saunders PT. Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis. J Clin Endocrinol Metab. 2014; 99(9):E1738–E1743.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Lessey BA, Higdon HL III, Miller SE, Price TA. Intraoperative detection of subtle endometriosis: a novel paradigm for detection and treatment of pelvic pain associated with the loss of peritoneal integrity. J Vis Exp. 2012;(70).

  76. Young VJ, Brown JK, Maybin J, Saunders PT, Duncan WC, Horne AW. Transforming growth factor-beta induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. J Clin Endocrinol Metab. 2014;99(9):3450–3459.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Young VJ, Brown JK, Saunders PT, Duncan WC, Horne AW. The peritoneum is both a source and target of TGF-beta in women with endometriosis. PLoS One. 2014;9(9):e106773.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  78. Tracey I, Bushnell MC. How neuroimaging studies have challenged us to rethink: is chronic pain a disease? J Pain. 2009;10(11):1113–1120.

    Article  PubMed  Google Scholar 

  79. Kaya S, Hermans L, Willems T, Roussel N, Meeus M. Central sensitization in urogynecological chronic pelvic pain: a systematic literature review. Pain Physician. 2013;16(4):291–308.

    PubMed  Google Scholar 

  80. Brawn J, Morotti M, Zondervan KT, Becker CM, Vincent K. Central changes associated with chronic pelvic pain and endo-metriosis. Hum Reprod Update. 2014;20(5):737–747.

    Article  PubMed  Google Scholar 

  81. Stratton P, Khachikyan I, Sinaii N, Ortiz R, Shah J. Association of chronic pelvic pain and endometriosis with signs of sensitization and myofascial pain. Obstet Gynecol. 2015;125(3):719–728.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Mechsner S, Schwarz J, Thode J, Loddenkemper C, Salomon DS, Ebert AD. Growth-associated protein 43-positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions. Fertil Steril. 2007;88(3):581–587.

    Article  PubMed  Google Scholar 

  83. Arnold J, Barcena de Arellano ML, Ruster C, et al. Imbalance between sympathetic and sensory innervation in peritoneal endometriosis. Brain Behav Immun. 2012;26(1):132–141.

    Article  CAS  PubMed  Google Scholar 

  84. Morotti M, Vincent K, Brawn J, Zondervan KT, Becker CM. Peripheral changes in endometriosis-associated pain. Hum Reprod Update. 2014;20(5):717–736.

    Article  PubMed  Google Scholar 

  85. Neziri AY, Bersinger NA, Andersen OK, Arendt-Nielsen L, Mueller MD, Curatolo M. Correlation between altered central pain processing and concentration of peritoneal fluid inflammatory cytokines in endometriosis patients with chronic pelvic pain. Reg Anesth Pain Med. 2014;39(3):181–184.

    Article  CAS  PubMed  Google Scholar 

  86. As-Sanie S, Harris RE, Napadow V, et al. Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study. Pain. 2012;153(5):1006–1014.

    Article  PubMed  PubMed Central  Google Scholar 

  87. May A. Structural brain imaging: a window into chronic pain. Neuroscientist. 2011;17(2):209–220.

    Article  PubMed  Google Scholar 

  88. Denk F, McMahon SB, Tracey I. Pain vulnerability: a neurobio-logical perspective. Nat Neurosci. 2014;17(2):192–200.

    Article  CAS  PubMed  Google Scholar 

  89. Berkley K. Primary dysmenorrhea: an urgent mandate. Pain Clin Updates. 2013;21(3).

    Google Scholar 

  90. Vincent K, Warnaby C, Stagg CJ, Moore J, Kennedy S, Tracey I. Dysmenorrhoea is associated with central changes in otherwise healthy women. Pain. 2011;152(9):1966–1975.

    Article  PubMed  Google Scholar 

  91. Tu C-H, Niddam DM, Chao H-T, et al. Abnormal cerebral metabolism during menstrual pain in primary dysmenorrhea. Neuroimage. 2009;47(1):28–35.

    Article  PubMed  Google Scholar 

  92. Tu C-H, Niddam DM, Chao H-T, et al. Brain morphological changes associated with cyclic menstrual pain. Pain. 2010;150(3):462–468.

    Article  PubMed  Google Scholar 

  93. Tu CH, Niddam DM, Yeh TC, et al. Menstrual pain is associated with rapid structural alterations in the brain. Pain. 2013;154(9):1718–1724.

    Article  PubMed  Google Scholar 

  94. Baranowski A, Abrams P, Berger RE, et al. Taxonomy of pelvic pain. Classification of Chronic Pain. 2nd ed. IASP; 2012. Published online by the International Association for the Study of Pain.

    Google Scholar 

  95. Turk DC, Dworkin RH, Allen RR, et al. Core outcome domains for chronic pain clinical trials: IMMPACT recommendations. Pain. 2003;106(3):337–345.

    Article  PubMed  Google Scholar 

  96. Vincent K, Kennedy S, Stratton P. Pain scoring in endometrio-sis: entry criteria and outcome measures for clinical trials. Report from the Art and Science of Endometriosis meeting. Fertil Steril. 2010;93(1):62–67.

    Article  PubMed  Google Scholar 

  97. Tripp DA, Nickel JC, Wang Y, et al. Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome. J Pain. 2006;7(10):697–708.

    Article  PubMed  Google Scholar 

  98. Tripp DA, Curtis Nickel J, Landis JR, Wang YL, Knauss JS. Predictors of quality of life and pain in chronic prostatitis/chronic pelvic pain syndrome: findings from the National Institutes of Health Chronic Prostatitis Cohort Study. BJU Int. 2004;94(9):1279–1282.

    Article  PubMed  Google Scholar 

  99. Martin CE, Johnson E, Wechter ME, Leserman J, Zolnoun DA. Catastrophizing: a predictor of persistent pain among women with endometriosis at 1 year. Hum Reprod. 2011;26(11):3078–3084.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Carey ET, Martin CE, Siedhoff MT, Bair ED, As-Sanie S. Biop-sychosocial correlates of persistent postsurgical pain in women with endometriosis. Int J Gynaecol Obstet. 2014;124(2):169–173.

    Article  PubMed  Google Scholar 

  101. Greaves E, Collins F, Esnal-Zufiaurre A, Giakoumelou S, Horne AW, Saunders PT. Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3. Endocrinology. 2014;155(10):4015–4026.

    Article  PubMed  CAS  Google Scholar 

  102. Greaves E, Temp J, Esnal-Zufiurre A, Mechsner S, Horne AW, Saunders PT. Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis. Am J Pathol. 2015;185(8):2286–2297.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282.

    Article  CAS  PubMed  Google Scholar 

  104. Alvarez P, Bogen O, Chen X, Giudice LC, Levine JD. Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis. Neuroscience. 2014;258:111–120.

    Article  CAS  PubMed  Google Scholar 

  105. Alvarez P, Giudice LC, Levine JD. Impact of surgical excision of lesions on pain in a rat model of endometriosis. Eur J Pain. 2015;19(1):103–110.

    Article  CAS  PubMed  Google Scholar 

  106. Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain. 2008;137(3):473–477.

    Article  PubMed  Google Scholar 

  107. Reimer M, Helfert SM, Baron R. Phenotyping neuropathic pain patients: implications for individual therapy and clinical trials. Curr Opin Support Palliat Care. 2014;8(2):124–129.

    Article  PubMed  Google Scholar 

  108. Gwilym SE, Oag HC, Tracey I, Carr AJ. Evidence that central sensitisation is present in patients with shoulder impingement syndrome and influences the outcome after surgery. J Bone Joint Surg Br. 2011;93(4):498–502.

    Article  CAS  PubMed  Google Scholar 

  109. Yarnitsky D, Crispel Y, Eisenberg E, et al. Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk. Pain. 2008;138(1):22–28.

    Article  PubMed  Google Scholar 

  110. Weissman-Fogel I, Granovsky Y, Crispel Y, et al. Enhanced presurgical pain temporal summation response predicts post-thoracotomy pain intensity during the acute postoperative phase. J Pain. 2009;10(6):628–636.

    Article  PubMed  Google Scholar 

  111. Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmer-man D, D’Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009;92(1):68–74.

    Article  PubMed  Google Scholar 

  112. Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril. 2008;90(2):247–257.

    Article  CAS  PubMed  Google Scholar 

  113. Garrido N, Navarro J, Garcia-Velasco J, Remoh J, Pellice A, Simon C. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update. 2002;8(1):95–103.

    Article  CAS  PubMed  Google Scholar 

  114. Shah DK. Diminished ovarian reserve and endometriosis: insult upon injury. Semin Reprod Med. 2013;31(2):144–149.

    Article  PubMed  Google Scholar 

  115. Aghajanova L, Giudice LC. Molecular evidence for differences in endometrium in severe versus mild endometriosis. Reprod Sci. 2011;18(3):229–251.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Stephansson O, Kieler H, Granath F, Falconer H. Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Hum Reprod. 2009;24(9):2341–2347.

    Article  PubMed  Google Scholar 

  117. Brosens I, Brosens JJ, Fusi L, Al-Sabbagh M, Kuroda K, Bena-giano G. Risks of adverse pregnancy outcome in endometriosis. Fertil Steril. 2012;98(1):30–35.

    Article  PubMed  Google Scholar 

  118. Simon C, Gutierrez A, Vidal A, et al. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod. 1994;9(4):725–729.

    Article  CAS  PubMed  Google Scholar 

  119. Pellicer A, Oliveira N, Ruiz A, Remohi J, Simon C. Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction. Hum Reprod. 1995;10(suppl 2):91–97.

    Article  PubMed  Google Scholar 

  120. Navarro J, Garrido N, Remohi J, Pellicer A. How does endome-triosis affect infertility? Obstet Gynecol Clin North Am. 2003;30(1):181–192.

    Article  PubMed  Google Scholar 

  121. Mansour G, Sharma RK, Agarwal A, Falcone T. Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility. Fer-til Steril. 2010;94(5):1894–1899.

    Article  Google Scholar 

  122. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007;88(6):1568–1572.

    Article  CAS  PubMed  Google Scholar 

  123. Suzuki T, Izumi S, Matsubayashi H, Awaji H, Yoshikata K, Makino T. Impact of ovarian endometrioma on oocytes and pregnancy outcome in in vitro fertilization. Fertil Steril. 2005;83(4):908–913.

    Article  PubMed  Google Scholar 

  124. Yanushpolsky EH, Best CL, Jackson KV, Clarke RN, Barbieri RL, Hornstein MD. Effects of endometriomas on ooccyte quality, embryo quality, and pregnancy rates in in vitro fertilization cycles: a prospective, case-controlled study. J Assist Reprod Genet. 1998;15(4):193–197.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Kumbak B, Kahraman S, Karlikaya G, Lacin S, Guney A. In vitro fertilization in normoresponder patients with endometrio-mas: comparison with basal simple ovarian cysts. Gynecol Obstet Invest. 2008;65(3):212–216.

    Article  PubMed  Google Scholar 

  126. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endome-triosis on in vitro fertilization. Fertil Steril. 2002;77(6):1148–1155.

    Article  PubMed  Google Scholar 

  127. May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endo-metrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637–653.

    Article  CAS  PubMed  Google Scholar 

  128. Lessey BA, Lebovic DI, Taylor RN. Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects. Semin Reprod Med. 2013;31(2):109–124.

    Article  PubMed  Google Scholar 

  129. Aghajanova L, Velarde MC, Giudice LC. Altered gene expression profiling in endometrium: evidence for progesterone resistance. Semin Reprod Med. 2010;28(1):51–58.

    Article  CAS  PubMed  Google Scholar 

  130. Tamaresis JS, Irwin JC, Goldfien GA, et al. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014;155(12):4986–4999.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  131. D’Hooghe TM, Debrock S, Hill JA, Meuleman C. Endometriosis and subfertility: is the relationship resolved? Semin Reprod Med. 2003;21(2):243–254.

    Article  PubMed  Google Scholar 

  132. Kuivasaari P, Hippelainen M, Anttila M, Heinonen S. Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod. 2005;20(11):3130–3135.

    Article  PubMed  Google Scholar 

  133. Leone Roberti Maggiore U, Ferrero S, Mangili G, et al. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update. 2016;22(1):70–103.

    Article  PubMed  Google Scholar 

  134. Vannuccini S, Clifton VL, Fraser IS, et al. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016;22(1):104–115.

    Article  CAS  PubMed  Google Scholar 

  135. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67(5):817-821.

  136. Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609–1615.

    Article  PubMed  Google Scholar 

  137. Exacoustos C, Manganaro L, Zupi E. Imaging for the evaluation of endometriosis and adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2014;28(5):655–681.

    Article  PubMed  Google Scholar 

  138. Piessens S, Healey M, Maher P, Tsaltas J, Rombauts L. Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound? Aust N Z J Obstet Gynaecol. 2014;54(5):462–468.

    Article  PubMed  Google Scholar 

  139. Dunselman GA, Vermeulen N, Becker C, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29(3):400–412.

    Article  CAS  PubMed  Google Scholar 

  140. Brosens I, Gordts S, Benagiano G. Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion. Hum Reprod. 2013;28(8):2026–2031.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  141. Reese KA, Reddy S, Rock JA. Endometriosis in an adolescent population: the Emory experience. J Pediatr Adolesc Gynecol. 1996;9(3):125–128.

    Article  CAS  PubMed  Google Scholar 

  142. Laufer MR, Goitein L, Bush M, Cramer DW, Emans SJ. Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy. J Pediatr Adolesc Gynecol. 1997;10(4):199–202.

    Article  CAS  PubMed  Google Scholar 

  143. Janssen EB, Rijkers AC, Hoppenbrouwers K, Meuleman C, D’Hooghe TM. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update. 2013;19(5):570–582.

    Article  CAS  PubMed  Google Scholar 

  144. Vicino M, Parazzini F, Cipriani S, Frontino G. Endometriosis in young women: the experience of GISE. J Pediatr Adolesc Gyne-col. 2010;23(4):223–225.

    Article  Google Scholar 

  145. Moore J, Copley S, Morris J, Lindsell D, Golding S, Kennedy S. A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis. Ultrasound Obstet Gynecol. 2002;20(6):630–634.

    Article  CAS  PubMed  Google Scholar 

  146. Hudelist G, English J, Thomas AE, Tinelli A, Singer CF, Keckstein J. Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2011;37(3):257–263.

    Article  CAS  PubMed  Google Scholar 

  147. Chapron C, Vieira M, Chopin N, et al. Accuracy of rectal endo-scopic ultrasonography and magnetic resonance imaging in the diagnosis of rectal involvement for patients presenting with deeply infiltrating endometriosis. Ultrasound Obstet Gynecol. 2004;24(2):175–179.

    Article  CAS  PubMed  Google Scholar 

  148. Schreinemacher MH, Backes WH, Slenter JM, et al. Towards endometriosis diagnosis by gadofosveset-trisodium enhanced magnetic resonance imaging. PLoS One. 2012;7(3):e33241.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  149. Manganaro L, Porpora MG, Vinci V, et al. Diffusion tensor imaging and tractography to evaluate sacral nerve root abnormalities in endometriosis-related pain: a pilot study. Eur Radiol. 2014;24(1):95–101.

    Article  CAS  PubMed  Google Scholar 

  150. Linnman C, Borsook D. Completing the pain circuit: recent advances in imaging pain and inflammation beyond the central nervous system. Rambam Maimonides Med J. 2013;4(4):e0026.

    Google Scholar 

  151. May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update. 2010;16(6):651–674.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Vodolazkaia A, El-Aalamat Y, Popovic D, et al. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endo-metriosis. Hum Reprod. 2012;27(9):2698–2711.

    Article  CAS  PubMed  Google Scholar 

  153. Gargett CE, Schwab KE, Brosens JJ, Puttemans P, Benagiano G, Brosens I. Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis. Mol Hum Reprod. 2014;20(7):591–598.

    Article  CAS  PubMed  Google Scholar 

  154. Brosens I, Gargett C, Gordts S, Brosens J, Benagiano G. Neonatal menstruation explains epidemiological links between fetomaternal conditions and adolescent endometriosis. J Endo-metriosis Pelvic Pain Disord. 2015;7(2):51–55.

    Google Scholar 

  155. Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endo-metriosis. Nat Genet. 2011;43(1):51–54.

    Article  CAS  PubMed  Google Scholar 

  156. Uno S, Zembutsu H, Hirasawa A, et al. A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet. 2010;42(8):707–710.

    Article  CAS  PubMed  Google Scholar 

  157. Brown J, Farquhar C. Endometriosis: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2014;3:CD009590.

    Google Scholar 

  158. Duffy JM, Arambage K, Correa FJ, et al. Laparoscopic surgery for endometriosis. Cochrane Database Syst Rev. 2014;4: CD011031.

    Google Scholar 

  159. Abrao MS, Petraglia F, Falcone T, Keckstein J, Osuga Y, Chapron C. Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management. Hum Reprod Update. 2015;21(3):329–339.

    Article  PubMed  Google Scholar 

  160. Muzii L, Di Tucci C, Di Feliciantonio M, Marchetti C, Perniola G, Panici PB. The effect of surgery for endometrioma on ovarian reserve evaluated by antral follicle count: a systematic review and meta-analysis. Hum Reprod. 2014;29(10):2190–2198.

    Article  CAS  PubMed  Google Scholar 

  161. Georgievska J, Sapunov S, Cekovska S, Vasilevska K. Effect of two laparoscopic techniques for treatment of ovarian endome-trioma on ovarian reserve. Med Arch. 2015;69(2):88–90.

    Article  PubMed  PubMed Central  Google Scholar 

  162. Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346.

    Article  PubMed  Google Scholar 

  163. Wiffen PJ, Derry S, Moore RA, et al. Antiepileptic drugs for neuropathic pain and fibromyalgia—an overview of Cochrane reviews. Cochrane Database Syst Rev. 2013;11:CD010567.

    Google Scholar 

  164. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitripty-line for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012;12:CD008242.

    PubMed  Google Scholar 

  165. Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389–2398.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  166. Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783–792.

    Article  CAS  PubMed  Google Scholar 

  167. Deley MC, Ballman KV, Marandet J, Sargent D. Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit. Clin Trials. 2012;9(3):283–292.

    Article  PubMed  PubMed Central  Google Scholar 

  168. Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.

    Google Scholar 

  169. Zhu X, Hamilton KD, McNicol ED. Acupuncture for pain in endo-metriosis. Cochrane Database Syst Rev. 2011;(9):CD007864.

  170. Hou L, Chen M, Zhang CK, Cho J, Zhao H. Guilt by rewiring: gene prioritization through network rewiring in genome wide association studies. Hum Mol Genet. 2014;23(10):2780–2790.

    Article  CAS  PubMed  Google Scholar 

  171. Yavuz E, Oktem M, Esinler I, Toru SA, Zeyneloglu HB. Genistein causes regression of endometriotic implants in the rat model. Fertil Steril. 2007;88(suppl 4):1129–1134.

    Google Scholar 

  172. Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Hum Reprod. 2009;24(3):608–618.

    Article  CAS  PubMed  Google Scholar 

  173. Ozcan Cenksoy P, Oktem M, Erdem O, et al. A potential novel treatment strategy: inhibition of angiogenesis and inflammation by resveratrol for regression of endometriosis in an experimental rat model. Gynecol Endocrinol. 2015;31(3):219–224.

    Article  CAS  PubMed  Google Scholar 

  174. Parazzini F, Vigano P, Candiani M, Fedele L. Diet and endome-triosis risk: a literature review. Reprod Biomed Online. 2013;26(4):323–336.

    Article  PubMed  Google Scholar 

  175. Hansen SO, Knudsen UB. Endometriosis, dysmenorrhoea and diet. Eur J Obstet Gynecol Reprod Biol. 2013;169(2):162–171.

    Article  CAS  PubMed  Google Scholar 

  176. Chiaffarino F, Bravi F, Cipriani S, et al. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur J Nutr. 2014;53(7):1573–1579.

    Article  CAS  PubMed  Google Scholar 

  177. Beste MT, Pfaffle-Doyle N, Prentice EA, et al. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Sci Transl Med. 2014; 6(222):222ra16.

    Google Scholar 

  178. Meuleman C, Tomassetti C, D’Hoore A, et al. Clinical outcome after CO(2) laser laparoscopic radical excision of endometriosis with colorectal wall invasion combined with laparoscopic segmental bowel resection and reanastomosis. Hum Reprod. 2011;26(9):2336–2343.

    Article  CAS  PubMed  Google Scholar 

  179. Meuleman C, Tomassetti C, D’Hoore A, et al. Surgical treatment of deeply infiltrating endometriosis with colorectal involvement. Hum Reprod Update. 2011;17(3):311–326.

    Article  PubMed  Google Scholar 

  180. Meuleman C, Tomassetti C, Wolthuis A, et al. Clinical outcome after radical excision of moderate-severe endometriosis with or without bowel resection and reanastomosis: a prospective cohort study. Ann Surg. 2014;259(3):522–531.

    Article  PubMed  Google Scholar 

  181. Meuleman C, Tomassetti C, D’Hooghe TM. Clinical outcome after laparoscopic radical excision of endometriosis and laparo-scopic segmental bowel resection. Curr Opin Obstet Gynecol. 2012;24(4):245–252.

    Article  PubMed  Google Scholar 

  182. Eltigani EE. Childbearing in five Arab countries. Stud Fam Plan. 2001;32(1):17–24.

    Article  CAS  Google Scholar 

  183. Adamson GD, Kennedy S, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometriosis. 2010;2(1):3–6.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics & Gynaecology, Royal Women’s Hospital, University of Melbourne, Level 7, 20 Flemington Rd, Parkville, Victoria, 3052, Australia

    A. W. Peter BSc PhD & G. David Adamson MD

  2. Palo Alto Medical Foundation Fertility Physicians of Northern California, Palo Alto, CA, USA

    Moamar Al-Jefout MD PhD

  3. World Endometriosis Research Foundation (WERF), London, UK

    Moamar Al-Jefout MD PhD, Andrew W. Horne MBChB PhD, Stacey A. Missmer ScD, Grant W. Montgomery PhD & Philippa T. Saunders PhD

  4. Mutah University, MawVtah, Jordan, UK

    Christian M. Becker MD

  5. Nuffield Department of Obstetrics & Gynaecology, Endometriosis Care Centre, Oxford, UK

    Thomas M. D’Hooghe MD PhD & Krina T. Zondervan DPhil

  6. University of Leuven (KU Leuven), Leuven, Belgium

    Gerard A. J. Dunselman MD PhD

  7. Department of Obstetrics & Gynaecology, Research Institute GROW, Maastricht University Medical Centre, Maastricht, the Netherlands

    Asgerally Fazleabas PhD

  8. Michigan State University, Michigan, MI, USA

    Linda C. Giudice MD PhD

  9. University of California, San Francisco, CA, USA

    Andrew W. Horne MBChB PhD

  10. World Endometriosis Society (WES), Vancouver, Canada

    Andrew W. Horne MBChB PhD, Stacey A. Missmer ScD, Luk Rombauts MD PhD & Philippa T. Saunders PhD

  11. MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

    M. Louise Hull BSc, MBChB PhD

  12. The Robinson Institute, University of Adelaide, Adelaide, Australia

    Lone Hummelshoj

  13. Harvard Schools of Medicine and Public Health, Boston, MA, USA

    Grant W. Montgomery PhD

  14. QIMR Berghofer Medical Research Institute, Brisbane, Australia

    Pamela Stratton MD

  15. NIH, Bethesda, MD, USA

    Robert N. Taylor MD PhD

  16. Wake Forest School of Medicine, Winston-Salem, NC, USA

    Luk Rombauts MD PhD

  17. Monash University, Clayton, Australia

    Philippa T. Saunders PhD

  18. MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK

    Katy Vincent MRCOG, DPhil

  19. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Krina T. Zondervan DPhil

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  1. A. W. Peter BSc PhD
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  2. G. David Adamson MD
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  3. Moamar Al-Jefout MD PhD
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  18. Katy Vincent MRCOG, DPhil
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  19. Krina T. Zondervan DPhil
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Consortia

WES/WERF Consortium for Research Priorities in Endometriosis

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Correspondence to A. W. Peter BSc PhD.

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Peter, A.W., Adamson, G.D., Al-Jefout, M. et al. Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis. Reprod. Sci. 24, 202–226 (2017). https://doi.org/10.1177/1933719116654991

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