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Is the Concept of Frontal–Subcortical Dementia Relevant to Schizophrenia?

Published online by Cambridge University Press:  02 January 2018

Christos Pantelis ,
Thomas R. E. Barnes  and
Hazel E. Nelson
Christos Pantelis*
Affiliation:
Charing Cross & Westminster Medical School, Schizophrenia Research Programme, Academic Unit, Horton Hospital, Long Grove Rd, Epsom, Surrey KT19 8PZ
Thomas R. E. Barnes
Affiliation:
Charing Cross & Westminster Medical School, Schizophrenia Research Programme, Academic Unit, Horton Hospital
Hazel E. Nelson
Affiliation:
Department of Psychology, Horton Hospital
*
∗Correspondence
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Abstract

A syndrome of subcortical dementia has been described in conditions predominantly affecting the basal ganglia or thalamus, structures that have also been implicated in the pathogenesis of schizophrenia. There are similarities between subcortical dementia and the type II syndrome of schizophrenia, in terms of clinical features, pattern of neuropsychological deficits, pathology, biochemistry and data from brain-imaging studies. These similarities raise the possibility that certain schizophrenic symptoms, particularly negative symptoms and disturbance of movement, may reflect subcortical pathology. Neuropsychological deficits of presumed frontal lobe origin have been reported in some schizophrenic subjects. The occurrence of such deficits in a condition in which frontal lobe pathology has not been clearly demonstrated may be explicable in terms of a subcortical deafferentation of the pre-frontal cortex.

Type
Review Article
Information
The British Journal of Psychiatry , Volume 160 , Issue 4 , April 1992 , pp. 442 - 460
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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References

Afifi, A. D. & Bergman, R. A. (1986) Basic Neuroscience: A Structural and Functional Approach, (2nd edn). Baltimore. Urban & Schwarzenberg.Google Scholar
Agid, Y., Ruberg, M., Dubois, B., et al (1984) Biochemical substrates of mental disturbances in Parkinson's disease. In Advances in Neurology, Vol. 40 (eds Hassler, R. G. & Christ, J. F.), pp. 211–218. New York: Raven Press.Google Scholar
Agid, Y., Ruberg, M., Dubois, B., et al (1987) Anatomical and biochemical concepts of subcortical dementia. In Cognitive Neurochemistry (eds Stahl, S. M., Iversen, S. D. & Goodman, E. C.), pp. 248–271. Oxford: Oxford University Press.Google Scholar
Albert, M. L., (1978) Subcortical dementia. In Alzheimer's Disease: Senile Dementia and Related Disorders, (ed. Katzman, R., Terry, R. D. & Bick, K. L.), pp. 173–180. New York: Raven Press.Google Scholar
Albert, M. L., Feldman, R. G. & Willis, A. L. (1974) The ‘subcortical dementia’ of progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry, 37, 121–130.Google Scholar
Alexander, G. E., DeLong, M. & Strick, P. E. (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381.CrossRefGoogle ScholarPubMed
Andreasen, N. C. (1987) The diagnosis of schizophrenia. Schizophrenia Bulletin, 13, 9–21.Google Scholar
Andreasen, N. C. (1989) Neural mechanism of negative symptoms. British Journal of Psychiatry, 155 (suppl. 7), 93–98.Google Scholar
Angrist, B., Rotrosen, J. & Gershon, S. (1980) Differential effects of amphetamine and neuroleptics on negative versus positive symptoms in schizophrenia. Psychopharmacology, 72, 17–19.CrossRefGoogle Scholar
Asarnow, R. F. & MacCrimmon, D. J. (1981) Span of apprehension deficits during the postpsychotic stages of schizophrenia. A replication and extension. Archives of General Psychiatry, 38, 1006–1011.Google Scholar
Babcock, H. (1930) An experiment in the measurement of mental deterioration, Archives of Psychology, 18, 100.Google Scholar
Babcock, H. (1933) Dementia Praecox, A Psychological Study. Lancaster, Philadelphia: The Science Press.CrossRefGoogle Scholar
Babcock, H. (1941) Time and the Mind. Cambridge, Massachusetts: Sci-Art Publishers.Google Scholar
Bachman, D. L. & Albert, M. L. (1984) The dopaminergic syndromes of dementia. In Brain Pathology (eds Pilleri, G. & Tagliavini, F.). Bern: Brain Anatomy Institute.Google Scholar
Barnes, T. R. E. (1988) Tardive dyskinesia: risk factors, pathophysiology and treatment. In Recent Advances In Clinical Psychiatry, 6 (ed. Granville-Grossman, K.), pp. 185–205. London: Churchill Livingstone.Google Scholar
Barnes, T. R. E. & Liddle, P. F. (1990) The evidence for the validity of negative symptoms. In Modern Problems of Pharmacopsychiatry, Schizophrenia: Positive and Negative Symptoms and Syndromes (ed. Andreasen, N. C.), pp. 43–72. Basel: Karger.Google Scholar
Bartels, M. & Themelis, J. (1983) Computerized tomography in tardive dyskinesia. Evidence of structural abnormalities in the basal ganglia system. Archiv fur Psychiatrie und Nervenkrankheiten, 233, 371–379.Google Scholar
Bauman, E. & Murray, D. J. (1968) Recognition versus recall in schizophrenia. Canadian Journal of Psychology, 22, 18–25.Google Scholar
Benson, D. F. (1983) Subcortical dementia: a clinical approach. In The Dementias (eds Mayeux, R. & Rosen, W. G.), pp. 185–194. New York: Raven Press.Google Scholar
Berman, K. F., Zec, R. F. & Weinberger, D. R. (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort. Archives of General Psychiatry, 43, 126–135.Google Scholar
Berman, K. F., Illowsky, B. P. & Weinberger, D. R. (1988) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioural specificity. Archives of General Psychiatry, 45, 616–622.CrossRefGoogle Scholar
Besson, J. A. O., Corrigan, F. M., Cherryman, G. R., et al (1987) Nuclear magnetic resonance imaging in chronic schizophrenia. British Journal of Psychiatry, 150, 161–163.Google Scholar
Blackwood, D. H. R., Whalley, L. J., Christie, J. E., et al (1987) Changes in auditory P3 event-related potential in schizophrenia and depression. British Journal of Psychiatry, 150, 201–210.Google Scholar
Bogerts, B., Meertz, C. & Schonfeldt-Bausch, R. (1985) Basal ganglia and limbic system pathology in schizophrenia: a morphometric study. Archives of General Psychiatry, 42, 784–791.Google Scholar
Bowman, M. & Lewis, M. S. (1980) Sites of subcortical damage in diseases which resemble schizophrenia. Neuropsychologia, 18, 597–601.Google Scholar
Brier, A., Wolkowitz, O. M., Doran, A. R., et al (1987) Neuroleptic responsivity of negative and positive symptoms in schizophrenia. American Journal of Psychiatry, 144, 1549–1555.Google Scholar
Broadhurst, A. H. (1957) Some Variables Affecting Speed of Mental Functioning in Schizophrenics. Unpublished PhD Thesis, University of London.Google Scholar
Brown, R., Colter, N., Corsellis, J. A. N., et al (1986) Postmortem evidence of structural brain changes in schizophrenia: differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Archives of General Psychiatry, 43, 36–42.Google Scholar
Brown, R., & Marsden, C. D. (1988) ‘Subcortical dementia’: the neuropsychological evidence. Neuroscience, 25, 363–387.CrossRefGoogle ScholarPubMed
Bruton, C. J., Crow, T. J., Frith, C. D., et al (1990) Schizophrenia and the brain: a prospective cliniconeuropathological study. Psychological Medicine, 20, 285–304.Google Scholar
Buchsbaum, M. S., Ingvar, D. H., Kessler, R., et al (1982) Cerebral glucography with positron tomography. Archives of General Psychiatry, 39, 251–259.Google Scholar
Buchsbaum, M. S., DeLisi, L. E., Holcomb, H. H., et al (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Archives of General Psychiatry, 71, 1159–1166.Google Scholar
Buchsbaum, M. S., & Haier, R. J. (1987) Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin, 13, 115–132.CrossRefGoogle ScholarPubMed
Buchsbaum, M. S., Wu, J. C., DeLisi, L. E., et al (1987) Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: differences between normal controls and schizophrenia patients. Biological Psychiatry, 22, 479–494.Google Scholar
Butters, N., Tarlow, S., Cermak, L. S., et al (1976) A comparison of the information processing deficits of patients with Huntington's chorea and Korsakoff's syndrome. Cortex, 12, 134–144.Google Scholar
Butters, N., Salmon, D. P., Granholm, E., et al (1987) Neuropsychological differentiation of amnesic and dementing states. In Cognitive Neurochemistry (eds Stahl, S. M., Iversen, S. D. & Goodman, E. C.), pp. 3–20. Oxford: Oxford University Press.Google Scholar
Campbell, D. (1957) A Study of Some Sensory-Motor Functions in Psychiatric Patients. Unpublished PhD Thesis, University of London.Google Scholar
Casanova, M. F., Hyde, T., Carosella, N., et al (1989) Concordance of familial nonarteriosclerotic mineralization of the basal ganglia and schizophrenia in two generations: A case report. (Abstract.) Schizophrenia Research, 2, 134.Google Scholar
Chouinard, G. & Jones, B. D. (1978) Schizophrenia as a dopamine-deficiency disease. Lancet, i, 99–100.CrossRefGoogle Scholar
Clausen, H. & Minas, H. (1987) Neuropsychological and computed tomographic findings in two subgroups of schizophrenia. In Brain Impairment: Proceedings of the Eleventh Annual Brain Impairment Conference (eds Field, C. D., Kneebone, A. C. & Reid, M. W.), pp. 139–146. Melbourne: Australian Society for the Study of Brain Impairment.Google Scholar
Cohen, B. D. (1956) Motivation and performance in schizophrenia. Journal of Abnormal and Social Psychology, 52, 186–190.CrossRefGoogle ScholarPubMed
Cohen, N. J. & Squire, L. R. (1980) Preserved learning and retention of pattern analysing skills in amnesia: dissociation of knowing how and knowing that. Science, 210, 207–210.Google Scholar
Coughlan, A. K. & Hollows, S. E. (1985) The Adult Memory and Information Processing Battery (AMIPB). Psychology Dept, St James' University Hospital, Beckett Street, Leeds LS9 7TF.Google Scholar
Cross, A. J., Crow, T. J. & Owen, F. (1981) 3H-flupenthixol binding in post-mortem brains of schizophrenics: evidence for a selective increase in dopamine D2 receptors. Psychopharmacology, 74, 122–124.Google Scholar
Crossman, A. R. (1987) Primate models of dyskinesia: the experimental approach to the study of basal ganglia-related involuntary movement disorders. Neuroscience, 21, 1–40.Google Scholar
Crosson, B. & Hughes, C. W. (1987) Role of the thalamus in language: is it related to schizophrenic thought disorder? Schizophrenia Bulletin, 13, 605–621.Google Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia: more than one disease process. British Medical Journal, i, 66–68.Google Scholar
Crow, T. J., Johnstone, E. C. & McClelland, H. A. (1976) The coincidence of schizophrenia and parkinsonism: some neurochemical implications. Psychological Medicine, 6, 227–233.CrossRefGoogle ScholarPubMed
Crow, T. J., Baker, H. F., Cross, A. J., et al (1979) Monoamine mechanisms in chronic schizophrenia: post-mortem neurochemical findings. British Journal of Psychiatry, 134, 249–256.Google Scholar
Crow, T. J., Owen, F., Cross, A. J., et al (1980) Neurotransmitter enzymes and receptors in post-mortem brain in schizophrenia: evidence that an increase in D2 dopamine receptors is associated with the Type 1 syndrome. In Transmitter Biochemistry of Human Brain Tissue (eds Usdin, E. & Riederer, P.). London: Macmillan.Google Scholar
Crow, T. J., Ball, J., Bloom, S. R., et al (1989) Schizophrenia as an anomaly of development of cerebral asymmetry: a post mortem study and a proposal concerning the genetic basis of the disease. Archives of General Psychiatry, 46, 1145–1150.Google Scholar
Cummings, J. L. (1985a) Organic delusions: phenomenology, anatomical correlations, and review. British Journal of Psychiatry, 146, 184–197.Google Scholar
Cummings, J. L. (1985b) Clinical Neuropsychiatry. New York: Grune & Stratton.Google Scholar
Cummings, J. L. (1985c) Psychosomatic aspects of movement disorders. Advances in Psychosomatic Medicine, 13, 111–132.Google Scholar
Cummings, J. L. (1986) Subcortical dementia: neuropsychology, neuropsychiatry, and pathophysiology. British Journal of Psychiatry, 149, 682–697.Google Scholar
Cummings, J. L. (1990) Subcortical Dementia. Oxford: Oxford University Press, Inc.Google Scholar
Cummings, J. L., Gosenfeld, L., Houlihan, J., et al (1983) Neuropsychiatric manifestations of idiopathic calcification of the basal ganglia: a case report and review. Biological Psychiatry, 18, 591–601.Google Scholar
Cutting, J. (1985) The Psychology of Schizophrenia, London: Churchill Livingstone.Google Scholar
Czudek, C. & Reynolds, G. P. (1988) Binding of (3H)SCH-23390 to post-mortem brain tissue in schizophrenia. British Journal of Pharmacology, 93 (suppl.), 166P.Google Scholar
D'Antona, R., Baron, J. C., Samson, Y., et al (1985) Subcortical dementia: frontal cortex hypometabolism detected by positron tomography in patients with progressive supranuclear palsy. Brain, 108, 785–799.Google Scholar
Davison, K. & Bagley, C. (1969) Schizophrenia-like psychoses associated with organic disorders. In Current Problems in Neuropsychiatry, (ed. Herrington, R. W.). Ashford: Headley Bros.Google Scholar
Deakin, J. F. W. (1988) The neurochemistry of schizophrenia. In Schizophrenia: The Major Issues (eds Bebbington, P. & McGuffin, P.), pp. 56–69. London: Heinmann & The Mental Health Foundation.Google Scholar
Deakin, J. F. W., Slater, P., Simpson, M. D. C., et al (1989) Frontal cortical and left temporal glutamatergic dysfunction of schizophrenia. Journal of Neurochemistry, 52, 1781–1786.Google Scholar
DeKeyser, J., Dierckx, R., Vanderheyden, P., et al (1988) D, dopamine receptors in human putamen, frontal cortex and calf retina: differences in guanine nucleotide regulation of agonist binding and adenylate cyclase stimulation. Brain Research, 443, 77–84.Google Scholar
DeLong, M. R., Alexander, G. E., Miller, W. C., et al (1990) Anatomical and functional aspects of basal ganglia–thalamocortical circuits. In Function and Dysfunction in the Basal Ganglia, (eds Franks, A. J., Ironside, J. W., Mindham, H. S., et al), pp. 3–32. Manchester: Manchester University Press.Google Scholar
Dening, T. R. & Berrios, G. E. (1989) Wilson's disease: a prospective study of psychopathology in 31 cases. British Journal of Psychiatry, 155, 206–213.CrossRefGoogle ScholarPubMed
Dewan, M. J., Pandurangi, A. K., Lee, S. H., et al (1983) Central brain morphology in chronic schizophrenia patients: a controlled CT study. Biological Psychiatry, 18, 1133–1140.Google Scholar
Dewhurst, K., Oliver, J., Trick, K. L. K., et al (1969) Neuropsychiatric aspects of Huntington's disease. Confinia Neurologica, 31, 258–268.Google Scholar
Divac, I. (1984) The neostriatum viewed orthogonally. CIBA Foundation Symposium on Function of the Basal Ganglia, 107, 201–221.Google Scholar
Dubois, B., Pillon, B., Legault, F., et al (1988) Slowing in cognitive processing in progressive supranuclear palsy. Archives of Neurology, 45, 1194–1199.Google Scholar
Duncan, C. C. (1988) Event-related brain potentials: a window on information processing in schizophrenia. Schizophrenia Bulletin, 14, 199–203.CrossRefGoogle ScholarPubMed
Early, T. S., Reiman, E. M., Raichle, M. E., et al (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proceedings of the National Academy of Science, 84, 561–563.Google Scholar
Ebmeier, K. P., Potter, D. D., Cochrane, R. H. B., et al (1990) P300 and smooth eye pursuit: concordance of abnormalities and relation to clinical features in DSM–III schizophrenia. Acta Psychiatrica Scandinavica, 82, 283–288.Google Scholar
Eslinger, P. J. & Damasio, A. R. (1986) Preserved motor learning in Alzheimer's disease: implications for anatomy and behaviour. Journal of Neuroscience, 6, 3006–3009.Google Scholar
Eysenck, H. J. (1968) Handbook of Abnormal Psychology. An Experimental Approach. London: Pitman Medical.Google Scholar
Eysenck, H. J., Granger, G. W. & Brengelmann, J. C. (1957) Perceptual Processes and Mental Illness. Maudsley Monograph No. 2. London: Institute of Psychiatry.Google Scholar
Farde, L., Pauli, S., Hall, H., et al (1988) Stereoselective binding of 11C-raclopride in living human brain: a search for extrastriatal central D2 dopamine receptors by PET. Psychopharmacology, 94, 471–478.Google Scholar
Farde, L., Wiesel, F. A., Stone-Elander, S., et al (1990) D2 dopamine receptors in neuroleptic-naive schizophrenic patients. Archives of General Psychiatry, 47, 213–219.Google Scholar
Farkas, T., Wolf, A. P., Jaeger, J., et al (1984) Regional brain glucose metabolism in chronic schizophrenia. Archives of General Psychiatry, 41, 293–300.Google Scholar
Fisher, J. M., Kennedy, J. L., Caine, E. D., et al (1983) Dementia in Huntington's disease: a cross-sectional analysis of intellectual decline. In The Dementias (eds Mayeux, R. & Rosen, W. G.), pp. 229–238. New York: Raven Press.Google Scholar
Flor Henry, P. (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia, 1, 117–142.Google Scholar
Francis, A. F. & Freeman, H. (1984) Psychiatric abnormality and brain calcification over four generations. Journal of Nervous and Mental Diseases, 172, 166–170.Google Scholar
Freedman, M. & Oscar-Berman, M. (1986a) Selective delayed response deficits in Parkinson's and Alzheimer's disease. Archives of Neurology, 43, 886–890.Google Scholar
Freedman, M. & Oscar-Berman, M. (1986b) Comparative neuropsychology of cortical and subcortical dementia. Canadian Journal of Neurological Sciences, 13, 410–414.Google Scholar
Freedman, M. (1987) Tactile discrimination learning deficits in Parkinson's and Alzheimer's disease. Archives of Neurology, 44, 394–398.Google Scholar
Friedman, D. (1992) Endogenous scalp-recorded brain potentials in schizophrenia: a methodological review. In Handbook of Schizophrenia, Vol. 5 (eds Steinhauer, S., Gruzelier, J. H. & Zubin, J.). Amsterdam: Elsevier (in press).Google Scholar
Frith, C. D. & Done, D. J. (1988) Towards a neuropsychology of schizophrenia. British Journal of Psychiatry, 153, 437–443.Google Scholar
Gibb, W. R. G. (1989) Dementia and Parkinson's disease. British Journal of Psychiatry, 154, 596–614.Google Scholar
Goldberg, S. C. (1985) Negative and deficit symptoms in schizophrenia do respond to neuroleptics. Schizophrenia Bulletin, 11, 453–456.Google Scholar
Goldberg, T. E., Weinberger, D. R., Berman, K. F., et al (1987) Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. Archives of General Psychiatry, 44, 1008–1014.Google Scholar
Goldberg, T. E., Weinberger, D. R., (1988) Probing prefrontal function in schizophrenia with neuropsychological paradigms. Schizophrenia Bulletin, 14, 179–183.Google Scholar
Goldberg, T. E., Ragland, J. D., Weinberger, D. R., et al (1989) Neuropsychological functioning in monozygotic twins discordant for schizophrenia. Schizophrenia Research, 2, 63.Google Scholar
Goldberg, T. E., Berman, K. F., Mohr, E., et al (1990a) Regional cerebral blood flow and cognitive function in Huntington's disease and schizophrenia. A comparison of patients matched for performance on a pre frontal-type task. Archives of Neurology 47, 418–422.Google Scholar
Goldberg, T. E., Saint-Cyr, J. E. & Weinberger, D. R. (1990b) Assessment of procedural learning and problem solving in schizophrenic patients by Tower of Hanoi type tasks, Journal of Neuropsychiatry and Clinical Neuroscience, 2, 165–173.Google Scholar
Goldberg, T. E., Fuller Torrey, E., Gold, J. M., et al (1992) Learning and memory in monozygotic twins discordant for schizophrenia. Journal of Abnormal Psychology (in press).Google Scholar
Golden, C. J., Graber, B., Coffman, J., et al (1981) Structural brain deficits in schizophrenia: identification by computed tomographic scan density measurements. Archives of General Psychiatry, 38, 1014–1017.Google Scholar
Goldman-Rakic, P. S., Isseroff, A., Schwartz, M. L., et al (1983) The neurobiology of cognitive development. In Handbook of Child Psychology, Vol. II (eds Haith, M. M. & Campos, J. J.), pp. 281–344. New York: John Wiley.Google Scholar
Goodwin, F. K., Brodie, H. K. H., Murphy, D. L., et al (1970) Administration of a peripheral decarboxylase inhibitor with l-dopa to depressed patients. Lancet, i, 908–911.CrossRefGoogle Scholar
Gotham, A. M., Brown, R. G. & Marsden, C. D. (1988) ‘Frontal’ cognitive function in patients with Parkinson's disease ‘on’ and ‘off’ levodopa. Brain, 111, 299–321.Google Scholar
Grafman, J., Weingartner, H., Newhouse, P. A., et al (1990) Implicit learning in patients with Alzheimer's disease.Google Scholar
Pharmacopsychiatry, 23, 94–101.Google Scholar
Gray, J. A., Feldon, J., Rawlins, J. N. P., et al (1991) The neuropsychology of schizophrenia. Behavioural and Brain Sciences, 14, 1–84.Google Scholar
Gur, R. E., Resnick, S. M., Alavi, A., et al (1987a) Regional brain function in schizophrenia. I. A positron emission tomography study. Archives of General Psychiatry, 44, 119–125.Google Scholar
Gur, R. E., Resnick, S. M., Gur, R. C., et al (1987b) Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Archives of General Psychiatry, 44, 126–129.Google Scholar
Hall, H., Farde, L. & Sedvall, G. (1988) Human dopamine receptor subtypes – in vitro binding analysis using 3H-SCH 2339 and 3H-raclopride. Journal of Neural Transmission, 73, 7–21.Google Scholar
Harris, A. & Metcalfe, M. (1956) Inappropriate affect, Journal of Neurology and Psychiatry, 19, 308–313.Google Scholar
Hassler, R. (1953) Extrapyramidal-motorische systeme und Erkrankungen. In Handbuch der Innerin Medezin, Vol. 3, pp. 676–904. Berlin: Springer.Google Scholar
Hausmann, M. F. (1933) A method to objectively demonstrate thinking difficulties. American Journal of Psychiatry, 13, 613–625.Google Scholar
Heindel, W. C., Butters, N. & Salmon, D. P. (1987) Impaired motor skill learning associated with neostriatal dysfunction (abstract). Journal of Clinical and Experimental Neuropsychology, 9, 18.Google Scholar
Heindel, W. C., Butters, N. & Salmon, D. P. (1988) Impaired learning of a motor skill in patients with Huntington's disease. Behavioural Neuroscience, 102, 141–147.Google Scholar
Hemsley, D. R. (1982) Cognitive impairment in schizophrenia. In The Pathology and Psychology of Cognition (ed. Burton, A.), pp. 169–203. London: Methuen.Google Scholar
Hess, E. J., Bracha, H. S., Kleinman, J. E., et al (1987) Dopamine receptor subtype imbalance in schizophrenia. Life Sciences, 40, 1487–1497.Google Scholar
Hirsch, S. R., Jolley, A. & Barnes, T. R. E. (1990) Are depressive symptoms part of the schizophrenic syndrome? In Depression in Schizophrenia (ed. DeLisi, L. E.), pp. 25–37. Washington: American Psychiatric Press.Google Scholar
Hornykiewicz, O. (1973) Parkinson's disease: from brain homogenate to treatment. Federation Proceedings, 32, 183–190.Google Scholar
Huber, S. J., Shuttleworth, E. C., Paulson, G. W., et al (1986) Cortical versus subcortical dementia. Archives of Neurology, 43, 392–394.Google Scholar
Iversen, S. D. (1988) Is it possible to model psychotic states in animals? Journal of Psychopharmacology, 1, 154–176.Google Scholar
Jackson, J. A. & Immerman, S. L. (1919) A case of pseudosclerosis associated with a psychosis. Journal of Nervous and Mental Disease, 49, 5–13.Google Scholar
Jakob, H. & Beckmann, H. (1986) Perinatal developmental disturbances in adopted and non-adopted schizophrenics and controls. Acta Psychiatrica Scandinavica, 62 (suppl. 285), 338–345.Google Scholar
Jeste, D. V., Karson, C. N., Iager, A. C., et al (1984a) Association of abnormal involuntary movement and negative symptoms. Psychopharmacology Bulletin, 20, 380–381.Google Scholar
Jeste, D. V., Karson, C. N. & Wyatt, R. J. (1984b) Movement disorders and psychopathology. In Neuropsychiatric Movement Disorders (eds Jeste, D. V. & Wyatt, R. J.), pp. 119–150. Washington, DC: American Psychiatric Press.Google Scholar
Jones, B., Labelle, A. & Grimes, D. (1989) Neural implants in Parkinson's disease: implications for schizophrenia (abstract). Schizophrenia Research, 2, 102.Google Scholar
Kahlbaum, K. L. (1874) Catatonia, (trans. (1973) Levij, Y. & Priden, T., Baltimore: Johns Hopkins University Press.)Google Scholar
Keddie, K. M. G. (1969) Hereditary ataxia presumed to be of the Menzel type, complicated by paranoid psychosis, in a mother and two sons. Journal of Neurology, Neurosurgery, and Psychiatry, 32, 82–87.Google Scholar
Kessell, R. (1955) An Investigation into Some of the Factors Affecting Speed of Response in Psychiatric Patients with Special Reference to Distraction. Unpublished PhD Thesis, University of London.Google Scholar
Kish, S. J., Chang, L. J., Mirchandani, L., et al (1985) Progressive supranuclear palsy: relationship between extrapyramidal disturbance, dementia and brain neurotransmitter markers. Annals of Neurology, 18, 530–536.CrossRefGoogle ScholarPubMed
Kleinman, J. E., Casanova, M. F. & Jaskiw, G. E. (1988) The neuropathology of schizophrenia. Schizophrenia Bulletin, 14, 209–216.Google Scholar
Knight, R. T. (1988) Electrophysiology in behavioural neurology. In Principles of Behavioural Neurology (ed. Marsel Mesulam, M.), pp. 327–346. Philadelphia: F. A. Davis.Google Scholar
Knights, A. & Hirsch, S. R. (1981) “Revealed” depression and drug treatment for schizophrenia. Archives of General Psychiatry, 38, 806–811.Google Scholar
Koh, S. D. (1978) Remembering of verbal material by schizophrenic young adults. In Language and Cognition in Schizophrenia (ed. Schwartz, S.). Hillsdale: Laurence Erlbaum.Google Scholar
Koh, S. D., Kayton, L. & Schwartz, C. (1974) The structure of word-storage in the permanent memory of nonpsychotic schizophrenics. Journal of Consulting and Clinical Psychology, 42, 879–887.Google Scholar
Koh, S. D. & Peterson, E. A. (1978) Encoding orientation and the remembering of schizophrenic young adults. Journal of Abnormal Psychology, 87, 303.Google Scholar
Kraepelin, E. (1913) Dementia Praecox and Paraphrenia (trans. (1919) Barclay, R. M., Edinburgh: Livingstone.)Google Scholar
Langston, J. W. (1987) MPTP: the promise of a new neurotoxin. In Movement Disorders 2 (eds Marsden, C. D. & Fahn, S.), pp. 73–90. London: Butterworths.Google Scholar
Langston, J. W. & Tetrud, J. W. (1988) MPTP-induced Parkinsonism in humans: new insights into Parkinson's disease. In Recent Advances in Clinical Neurology, 5 (ed. Kennard, C.), pp. 153–173. London: Churchill Livingstone.Google Scholar
Lantos, P. L. (1988) The neuropathology of schizophrenia: a critical review of recent work. In Schizophrenia, The Major Issues (eds Bebbington, P. & McGuffin, P.), pp. 73–89. Oxford: Heinemann Professional & the Mental Health Foundation.Google Scholar
Laplane, D., Baulac, M., Widlocher, D. et al (1984) Pure psychic akinesia with bilateral lesions of basal ganglia. Journal of Neurology, Neurosurgery, and Psychiatry, 47, 377–385.Google Scholar
Largen, J. W., Smith, R. C., Calderon, M., et al (1984) Abnormalities of brain structure and density in schizophrenics. Biological Psychiatry, 19, 991–1013.Google Scholar
Lecrubier, Y., Puech, A. J., Simon, P., et al (1980) Schizophrenic: hyper- ou hypofonctionnement du systeme dopaminergique: une hypothese bipolaire. Psychologie Medicate, 12, 2431–2441.Google Scholar
Lee, T. & Seeman, P. (1980) Elevation of brain neuroleptic/dopamine receptors in schizophrenia. American Journal of Psychiatry, 137, 191–197.Google Scholar
Lenzenweger, M. F., Dworkin, R. H. & Wethington, E. (1989) Models of positive and negative symptoms in schizophrenia: an empirical evaluation of latent structures. Journal of Abnormal Psychology, 98, 62–70.Google Scholar
Lesch, A. & Bogerts, B. (1984) The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter. European Archives of Psychiatry and Neurological Sciences, 234, 212–219.Google Scholar
Lewis, S. W. (1989) Congenital risk factors for schizophrenia. Psychological Medicine, 19, 5–13.Google Scholar
Liddle, P. F. (1987a) The symptoms of chronic schizophrenia: a re-examination of the positive-negative dichotomy. British Journal of Psychiatry, 151, 145–151.Google Scholar
Liddle, P. F. (1987b) Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychological Medicine, 17, 49–57.Google Scholar
Liddle, P. F. (1990) Prefrontal and subcortical dysfunction in schizophrenia. In International Perspectives in Schizophrenia: Biological, Social and Epidemiological Findings (ed. Weller, M.), pp. 85–95. London: John Libbey.Google Scholar
Liddle, P. F. & Barnes, T. R. E. (1990) The symptoms of chronic schizophrenia. British Journal of Psychiatry, 157, 558–561.Google Scholar
Lidsky, T. I., Weinhold, P. M. & Levine, F. M. (1979) Implications of basal ganglionic dysfunction for schizophrenia. Biological Psychiatry, 14, 3–12.Google Scholar
Mackay, A. V. P. (1980) Positive and negative schizophrenic symptoms and the role of dopamine. British Journal of Psychiatry, 137, 379–386.Google Scholar
Mackay, A. V. P., Bird, E. D., Iverson, L. et al (1980) Dopaminergic abnormalities in post-mortem schizophrenic brain. Advances in Biochemistry and Psychopharmacology, 24, 325–333.Google Scholar
Martone, M., Butters, N., Payne, M., et al (1984) Dissociations between skill learning and verbal recognition in amnesia and dementia. Archives of Neurology, 41, 965–970.Google Scholar
Matussek, N., Benkert, O., Schneider, K., et al (1970) l-dopa plus decarboxylase inhibitor in depression. Lancet, ii, 660–661.Google Scholar
Mayeux, R. & Stern, Y. (1987) Subcortical dementia. Archives of Neurology, 44, 129–131.Google Scholar
Mayeux, R., Stern, Y. & Rosen, J., et al (1981) Subcortical dementia: A recognisable clinical entity. Annals of Neurology, 10, 100–101.Google Scholar
Mayeux, R., Stern, Y. & Rosen, J., et al (1983) Is “subcortical dementia” a recognisable clinical entity? Annals of Neurology, 14, 278–283.Google Scholar
McGrath, J. (1991) Ordering thoughts on thought disorder. British Journal of Psychiatry, 158, 307–316.Google Scholar
McHugh, P. R. & Folstein, M. (1975) Psychiatric syndromes of Huntington's chorea: a clinical and phenomenological study. In Psychiatric Aspects of Neurologic Disease (eds Benson, D. F. & Blumer, D.). New York: Grune & Stratton.Google Scholar
McKenna, P. J. (1990) Basal ganglia dysfunction in schizophrenia? In Function and Dysfunction in the Basal Ganglia (eds Franks, A. J., Ironside, J. W., Mindham, R. H. S., et al) pp. 247 255. Manchester: Manchester University Press.Google Scholar
McKenna, P. J., Tamlyn, D., Lund, C. E., et al (1990) Amnesic syndrome in schizophrenia. Psychological Medicine, 20, 967–972.Google Scholar
Meltzer, H. Y. (1987) Biological studies in schizophrenia. Schizophrenia Bulletin, 13, 77–111.Google Scholar
Mettler, F. A. (1955) Perceptual capacity, functions of the striatum and schizophrenia. Psychiatric Quarterly, 29, 89.Google Scholar
Mishkin, M. & Petri, H. L. (1984) Memories and habits. In Neurobiology of Learning and Memory (eds Lynch, G., McGaugh, J. L. & Weinberger, D. R.), pp. 287–296. New York: Guilford.Google Scholar
Morris, R. G., Evendon, J. L., Sahakian, B. J., et al (1987) Computer-aided assessment studies of neuropsychological deficits in Alzheimer-type dementia and Parkinson's disease. In Cognitive Neurochemistry (eds Stahl, S. M., Iversen, S. D. & Goodman, E. C.), pp. 21–36. Oxford: Oxford University Press.Google Scholar
Morris, R. G., Downes, J. J., Sahakian, B. J., et al (1988) Planning and spatial working memory in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 51, 757–766.Google Scholar
Murray, R. M. & Lewis, S. W. (1987) Is schizophrenia a neurodevelopmental disorder? British Medical Journal, 295, 681–682.Google Scholar
Murray, R. M., Lewis, S. W. & Owen, M. J., et al (1988) The neurodevelopmental origins of dementia praecox. In Schizophrenia: The Major Issues (eds Bebbington, P. & McGuffin, P.), pp. 90–106. London: Heinemann Professional & the Mental Health Foundation.Google Scholar
Nachmani, G. & Cohen, B. D. (1969) Recall and recognition free learning in schizophrenics. Journal of Abnormal Psychology, 74, 511–516.Google Scholar
Nauta, H. J. W. (1986) A simplified perspective on the basal ganglia and their relation to the limbic system. In The Limbic System: Functional Organization and Clinical Disorders (eds Doane, B. K. & Livingston, K. E.), pp. 43–54. New York: Raven Press.Google Scholar
Naville, F. (1922) Les complications des sequelles mentales de l'encephalite epidemique. L'encephale, 17, 369–375.Google Scholar
Nelson, H. E., Pantelis, C., Carruthers, K., et al (1990) Cognitive functioning and symptomatology in chronic schizophrenia. Psychological Medicine, 20, 357–365.Google Scholar
Ogilvie, B. C. (1954) A Study of Intellectual Slowness in Schizophrenia. Unpublished PhD Thesis, University of London.Google Scholar
Oke, A. F. & Adams, R. N. (1987) Elevated thalamic dopamine: possible link to sensory dysfunctions in schizophrenia. Schizophrenia Research, 13, 589–604.Google Scholar
Owen, A. M., Downes, J. J., Sahakian, B. J., et al (1990) Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia, 28, 1021–1034.Google Scholar
Owen, F., Cross, A. J., Crow, T. J., et al (1978) Increased dopamine receptor sensitivity in schizophrenia. Lancet, ii, 223–226.Google Scholar
Owens, D. G. C. & Johnstone, E. C. (1980) The disabilities of chronic schizophrenia – their nature and factors contributing to their development. British Journal of Psychiatry, 136, 384–395.Google Scholar
Owens, D. G. C., Johnstone, E. C. & Frith, C. D. (1982) Spontaneous involuntary disorders of movement, their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. Archives of General Psychiatry, 39, 452–481.Google Scholar
Pakkenberg, B. & Gundersen, H. J. G. (1989) New stereological method for obtaining unbiased and efficient estimates of total nerve cell number in human brain areas. Exemplified by mediodorsal thalamic nucleus in schizophrenics. Acta Pathologica, Microbiologica, et Immunologica Scandinavica, 97, 677–681.Google Scholar
Pantelis, C., Barnes, T. R. E. & Nelson, H. E. (1989) A pilot study of subcortical dementia in schizophrenia (abstract). Schizophrenia Research, 2, 69.Google Scholar
Patterson, T. (1987) Studies toward the subcortical pathogenesis of schizophrenia. Schizophrenia Bulletin, 13, 555–576.Google Scholar
Payne, R. W. & Hewlett, J. H. G. (1960) Thought disorder in psychotic patients. In Experiments in Personality: Vol II. Psychodiagnostics and Psychodynamics, (ed. Eysenck, H. J.), pp. 3–104. London: Routledge and Kegan Paul.Google Scholar
Pfefferbaum, A., Wenegrat, B. G., Ford, J. M., et al (1984) Clinical application of the P3 component of the event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalography and Clinical Neurophysiology, 59, 104–124.Google Scholar
Pimoule, C., Schoemaker, H., Reynolds, G. P., et al (1985) (3H)SCH-23390 labelled D1 dopamine receptors are unchanged in schizophrenia and Parkinson's disease. European Journal of Pharmacology, 114, 235–237.Google Scholar
Pogue-Geile, M. F. & Harrow, M. (1985) Negative symptoms in schizophrenia: their longitudinal course and prognostic importance. Schizophrenia Bulletin, 11, 427–439.Google Scholar
Prasad, C. M., Casanova, M. F., Stein, B., et al (1989) Basal ganglia mineralisation in schizophrenia (Abstract). Schizophrenia Research, 1, 139.Google Scholar
Pycock, C. J., Kerwin, R. W. & Carter, C. J. (1980) Effect of lesion of cortical dopamine terminals on subcortical dopamine in rats. Nature, 286, 74–77.Google Scholar
Rafal, R. D., Posner, M. L., Walker, J. A., et al (1984) Cognition and the basal ganglia. Separating mental and motor components of performance in Parkinson's disease. Brain, 107, 1083–1094.Google Scholar
Rapoport, J. L. (1990) Obsessive compulsive disorder and basal ganglia dysfunction. Psychological Medicine, 20, 465–469.Google Scholar
Reynolds, G. P. (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature, 305, 527–529.Google Scholar
Reynolds, G. P. (1987) Post-mortem neurochemical studies in schizophrenia. In Search for the Causes of Schizophrenia (eds Haefner, H., Gattaz, W. F. & Janzarik, W.), pp. 236–240. Berlin: Springer-Verlag.Google Scholar
Reynolds, G. P. (1989) Neurochemical pathology of schizophrenia. British Journal of Psychiatry, 155, 305–316.Google Scholar
Robbins, T. W. (1990) The case for fronto-striatal dysfunction in schizophrenia. Schizophrenia Bulletin, 16, 391–402.Google Scholar
Reynolds, G. P. (1991) Cognitive deficits in schizophrenia and Parkinson's disease: neural basis and the role of dopamine. In The Mesolimbic Dopamine System: From Motivation to Action (eds Willner, P. & Scheel-Kruger, J.), pp. 497–528. Chichester: John Wiley.Google Scholar
Rogers, D. (1985) The motor disorders of severe psychiatric illness: a conflict of paradigms. British Journal of Psychiatry, 147, 221–232.Google Scholar
Rogers, D. (1986) Bradyphrenia in Parkinsonism: a historical review. Psychological Medicine, 16, 257–265.Google Scholar
Rogers, D. (1988) Bradyphrenia in Parkinson's disease. British Journal of Hospital Medicine, 39, 128–130.Google Scholar
Rogers, D., Lees, A. J., Smith, E., et al (1987) Bradyphrenia in Parkinson's disease and psychomotor retardation in depressive illness. An experimental study. Brain, 110, 761–776.Google Scholar
Ron, M. A. (1988) Diagnostic progress in dementia. In Recent Advances in Clinical Psychiatry, 6 (ed. Granville-Grossman, K.), pp. 51–67. London: Churchill Livingstone.Google Scholar
Rosen, T. J. (1987) Cortical versus subcortical dementia: neuropsychological similarities. Archives of Neurology, 44, 131.Google Scholar
Rosenbaum, G., MacKavey, W. R. & Grisell, J. L. (1957) Effects of biological and social motivation in schizophrenic reaction time. Journal of Abnormal and Social Psychology, 53, 364–368.Google Scholar
Rossi, A., Stratta, P., D'Albenzio, L., et al (1989) Quantitative computed tomographic study in schizophrenia: cerebral density and ventricle measures. Psychological Medicine, 19, 337–342.Google Scholar
Ruberg, M., Javoy-Agid, F., Hirsch, E., et al (1985) Dopaminergic and cholinergic lesions in progressive supranuclear palsy. Annals of Neurology, 18, 523–529.Google Scholar
Sagar, H. J., Cohen, N. J., Corkin, S., et al (1985) Dissociations among processes in remote memory. In Memory Dysfunctions: An Integration of Animal and Human Research from Preclinical and Clinical Perspectives (eds Olton, D. S., Gamzu, E. & Corkin, S.), pp. 533–535. New York: New York Academy of Science.Google Scholar
Sagar, H. J., & Sullivan, E. V. (1988) Patterns of cognitive impairment in dementia. In Recent Advances in Clinical Neurology, 5 (ed. Kennard, C.), pp. 47–86. London: Churchill Livingstone.Google Scholar
Sahakian, B. J., Morris, R. G., Evendon, J. L., et al (1988) A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain, 111, 695–718.Google Scholar
Saint-Cyr, J. A., Taylor, A. E. & Lang, A. E. (1988) Procedural learning and neostriatal dysfunction in man, Brain, 111, 941–959.Google Scholar
Sedvall, G., Farde, L. & Wiesel, F-A. (1987) Quantitative determination of D2 dopamine receptor characteristics in healthy human subjects and psychiatric patients. Life Sciences, 41, 813–816.Google Scholar
Seeman, P. (1980) Brain dopamine receptors. Pharmacological Review, 32, 229–313.Google Scholar
Senf, R., Huston, P. E. & Cohen, B. D. (1955) Thinking deficit in schizophrenia and changes with amytal. Journal of Abnormal Psychology, 50, 383–387.Google Scholar
Shallice, T. (1979) Case study approach in neuropsychological research. Journal of Clinical Neuropsychology, 1, 183–211.Google Scholar
Shallice, T. (1982) Specific impairments in planning. Philosophical Transactions of the Royal Society (London), B 298, 199–209.Google Scholar
Shapiro, M. B. & Nelson, E. H. (1955) An investigation of the nature of cognitive impairment in co-operative psychiatric patients. British Journal of Medical Psychology, 28, 239–256.Google Scholar
Sheppard, G., Manchanda, R., Gruzelier, J., et al (1983) O15 positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet, ii, 1448–1452.Google Scholar
Slater, E., Beard, A. & Glithero, E. (1963) Schizophrenia-like psychoses of epilepsy. British Journal of Psychiatry, 109, 95–150.Google Scholar
Snyder, E., Hillyard, S. A. & Galambos, R. (1980) Similarities and differences among the P3 waves to detected signals in three modalities. Psychophysiology, 17, 112–122.Google Scholar
Squire, L. R. (1986) Mechanisms of memory. Science, 232, 1612–1619.Google Scholar
St.Clair, D. M., Blackwood, D. H. R. & Muir, W. (1989) P300 abnormality in schizophrenic subtypes. Journal of Psychiatric Research, 23, 49–55.Google Scholar
Stern, Y. & Langston, J. W. (1985) Intellectual changes in patients with MPTP-induced parkinsonism. Neurology, 35, 1506–1509.Google Scholar
Stevens, J. R. (1982) Neuropathology of schizophrenia. Archives of General Psychiatry, 39, 1131–1139.Google Scholar
Stevens, J. R. (1990) Psychiatric consequences of temporal lobectomy for intractable seizures: a 20–30 year follow-up of 14 cases. Psychological Medicine, 20, 529–545.Google Scholar
Szechtman, H., Nahmias, C., Garnett, S., et al (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Archives of General Psychiatry, 45, 523–532.Google Scholar
Tagliavini, F., Pilleri, G., Bouras, C. et al (1984) The basal nucleus of Meynert in patients with progressive supranuclear palsy. Neuroscience Letters, 44, 37–42.Google Scholar
Taylor, A. E., Saint-Cyr, J. A. & Lang, A. E. (1986) Frontal lobe dysfunction in Parkinson's disease. Brain, 109, 845–883.Google Scholar
Traupman, K. L. (1975) Effects of categorization and imagery on recognition and recall by process and reactive schizophrenics. Journal of Abnormal Psychology, 75, 182–186.Google Scholar
Trimble, M. R. & Cummings, J. L. (1981) Neuropsychiatric disturbances following brainstem lesions. British Journal of Psychiatry, 138, 56–59.Google Scholar
Tweedy, J. R., Langer, K. G. & McDowell, F. H. (1982) The effect of semantic relations on the memory deficit associated with Parkinson's disease. Journal of Clinical Neuropsychology, 4, 235–247.Google Scholar
Van Kammen, D. P. & Boronow, J. J. (1988) Dextro-amphetamine diminishes negative symptoms in schizophrenia. International Journal of Clinical Psychopharmacology, 3, 111–121.Google Scholar
Vita, A. (1989) A computed tomographic study of brain density in schizophrenia (abstract). Schizophrenia Research, 2, 140.Google Scholar
Volkow, N. D., Wolf, A. P., Van Gelder, P., et al (1987) Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. American Journal of Psychiatry, 144, 151–158.Google Scholar
Waddington, J. L. (1989a) Schizophrenia, affective psychoses, and other disorders treated with neuroleptic drugs: The enigma of tardive dyskinesia, its neurological determinants, and the conflict of paradigms. International Review of Neurobiology, 31, 297–353.Google Scholar
Waddington, J. L. (1989b) Functional interactions between D1 and D2 dopamine receptor systems: their role in the regulation of psychomotor behaviour, putative mechanisms, and clinical relevance. Journal of Psychopharmacology, 3, 54–63.Google Scholar
Waddington, J. L. (1990) Neuroleptics visualised in schizophrenics by PET. British Journal of Psychiatry, 154, 433–436.Google Scholar
Waddington, J. L. & Crow, T. J. (1988) Abnormal involuntary movements and psychosis in the pre-neuroleptic era and in unmedicated patients: implications for the concept of tardive dyskinesia. In Tardive Dyskinesia: Biological Mechanisms and Clinical Aspects, (eds Wolf, M. E. & Mosnaim, A. D.). Washington, DC: American Psychiatric Press.Google Scholar
Wechsler, D. (1955) Manual For The Wechsler Adult Intelligence Scale. Psychological Corporation: New York.Google Scholar
Weinberger, D. R. (1987) Implications for normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–699.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N., et al (1979) Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735–739.Google Scholar
Weinberger, D. R., Torrey, E. F. & Zec, R. F. (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Archives of General Psychiatry, 43, 114–124.Google Scholar
Weinberger, D. R., Berman, K. F., Iadarola, M., et al (1988a) Prefrontal cortical blood flow and cognitive function in Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry, 51, 94–104.Google Scholar
Weinberger, D. R., Berman, K. F., & Illowsky, B. P. (1988b) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. Archives of General Psychiatry, 45, 609–615.Google Scholar
Whitehouse, P. J. (1986) The concept of subcortical and cortical dementia: another look. Annals of Neurology, 19, 1–6.Google Scholar
Wise, S. & Rapoport, J. L. (1989) Obsessive-compulsive disorder: is it basal ganglia dysfunction? In Obsessive–Compulsive Disorder in Children and Adolescents (ed. Rapoport, J. L.), pp. 327–346. Washington, DC: American Psychiatric Press.Google Scholar
Wolkin, A., Jaeger, J., Brodie, J. D., et al (1985) Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. American Journal of Psychiatry, 142, 564–571.Google Scholar
Wong, D. F., Wagner, H. N., Tune, L. E., et al (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234, 1558–1563.Google Scholar
Yates, A. J. (1966) Data-processing levels and thought disorder in schizophrenia. Australian Journal of Psychology, 18, 103–117.Google Scholar
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