ABSTRACT
The Port System is a compartmentalized dosage form that independently controls drug release time and drug release rate for multiple drugs and doses. Advantages associated with this drug delivery system include designing release profiles to optimize drug pharmacokinetics and/or pharmacodynamics and administering more than one dose or drug in a single unit to improve patient compliance. The release profiles that the Port System is capable of range from a zero-order release rate to a pulse to mimic an immediate-release tablet. The latter is particularly useful when the goal is to release drug in the lower ileum or colon. Additional technologies, such as dissolution rate or permeability enhancers, can be combined with the drug to enhance bioavailability.
