ABSTRACT
Focused research in the field of neuroscience needs a microenvironment with spatiotemporal fluidic control, which can be provided by microfluidic devices for guiding neuron development and dynamics in vitro. This chapter elaborates on microfluidic design biomimetics related to the nervous system. It discusses the re-creation of both neurodegenerative disorders and neural stem cell behavior blueprinting microfluidic platforms. The advantages and limitations of microfluidic devices in neuroscience are also emphasized. The chapter discuss the advancements in microfluidic devices related to neuroscience in terms of design at the cellular/tissue organization level. To study gradients, the microfluidic devices are a great choice as they can generate and maintain desired gradient profiles for a long period. These devices can be categorized into two types, flow-based and diffusion-based gradient generators. Microfluidic devices have low contamination risk, provide competent high-throughput experimentation, and lessen the cell population up to a few hundreds or even to the a level of single cell.
