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Role of surfactant and pH on dissolution properties of fenofibrate and glipizide—A technical note

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Summary and Conclusions

Depending on the dose size and solubility characteristics of low solubility drugs, a meaningful and discriminatory power of dissolution rate testing can be demonstrated. Saturation solubility of fenofibrate and glipizide in different media were determined. Solubility of fenofibrate increased directly with SLS concentration. For a 54-mg fenofibrate tablet, SLS at 0.025 M level is required for a discriminative dissolution test, while for 160-mg tablet, dissolution condition and levels of SLS should be optimized; higher concentrations may be effective (ie, 0.052 M, ∼1.5%). A pH 6.8 phosphate buffer medium is appropriate for glipizide 10-mg tablet dissolution study, when formulation ingredients include excipients with surface activity (eg, HPMC).

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Authors and Affiliations

  1. School of Pharmacy, Temple University, 3307 N Broad Street, 19140, Philadelphia, PA

    Shahla Jamzad & Reza Fassihi

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  1. Shahla Jamzad
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  2. Reza Fassihi
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Correspondence to Reza Fassihi.

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Published: April 7, 2006,

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Jamzad, S., Fassihi, R. Role of surfactant and pH on dissolution properties of fenofibrate and glipizide—A technical note. AAPS PharmSciTech 7, 33 (2006). https://doi.org/10.1208/pt070233

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  • DOI: https://doi.org/10.1208/pt070233

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