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Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note

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Summary and Conclusions

The ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH and by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity, and hydrophilicity.

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Authors and Affiliations

  1. Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, 411038, Pune, Maharashtra State, India

    Devika R. Bhumkar & Varsha B. Pokharkar

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  1. Devika R. Bhumkar
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  2. Varsha B. Pokharkar
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Correspondence to Varsha B. Pokharkar.

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Bhumkar, D.R., Pokharkar, V.B. Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note. AAPS PharmSciTech 7, 50 (2006). https://doi.org/10.1208/pt070250

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  • DOI: https://doi.org/10.1208/pt070250

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