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Effect of additives on the release of a model protein from PLGA microspheres

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Abstract

The purpose of this study was to investigate the effect of 2 additives, poly(ethylene glycol (PEG) 1000 and 1,2,3-tridecanoyl glycerol (tricaprin), on the physico-chemical characteristics and in vitro release of a model protein, bovine serum albumin (BSA), form poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres. BSA-loaded microspheres were prepared by the double emulsion solvent evaporation method. Additives were incorporated into microspheres to modify the release of protein. The addition of PEG 1000 and tricaprin changed the surface characteristics of microspheres from smooth and nonporous to porous and dimpled, respectively. The in vitro release profiles showed that the additives significantly (P<0.05) increased the early-stage release of BSA from microspheres.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, 58105, Fargo, ND

    Feirong Kang & Jagdish Singh

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  1. Feirong Kang
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  2. Jagdish Singh
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Correspondence to Jagdish Singh.

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Published: December 17, 2001

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Kang, F., Singh, J. Effect of additives on the release of a model protein from PLGA microspheres. AAPS PharmSciTech 2, 30 (2001). https://doi.org/10.1208/pt020430

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  • DOI: https://doi.org/10.1208/pt020430

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