Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-α Carriers: Pharmacokinetics and Anti-tumor Effects

Ya-Ping LI; Yuan-Ying PEI; Zhao-Hui ZHOU; Xian-Ying ZHANG; Zhou-Hui GU; Jian DING; Jian-Jun ZHOU; Xiu-Jian GAO; Jian-Hua ZHU

doi:10.1248/bpb.24.662

Regular Articles

Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-α Carriers: Pharmacokinetics and Anti-tumor Effects

Ya-Ping LI, Yuan-Ying PEI, Zhao-Hui ZHOU, Xian-Ying ZHANG, Zhou-Hui GU, Jian DING, Jian-Jun ZHOU, Xiu-Jian GAO, Jian-Hua ZHU

Author information

Ya-Ping LI
Department of Pharmaceutics, School of Pharmacy, Fudan University
Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
Yuan-Ying PEI
Department of Pharmaceutics, School of Pharmacy, Fudan University
Zhao-Hui ZHOU
Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
Xian-Ying ZHANG
Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
Zhou-Hui GU
Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
Jian DING
Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
Jian-Jun ZHOU
Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
Xiu-Jian GAO
Department of Pharmaceutics, School of Pharmacy, Fudan University
Jian-Hua ZHU
Department of Pharmaceutics, School of Pharmacy, Fudan University

Keywords: poly(ethylene glycol), poly(alkyl cyanoacrylate), nanoparticle, stealth, poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate), tumor necrosis factor-α

JOURNAL FREE ACCESS

2001 Volume 24 Issue 6 Pages 662-665

DOI https://doi.org/10.1248/bpb.24.662

Details

Abstract

The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-α (rHuTNF-α) encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles. Our experimental results showed that PEG-PHDCA nanoparticles could extend the half-life of rHuTNF-α to 7.42 h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-α in tumor. Compared with PHDCA nanoparticles and free rHuTNF-α, PEG-PHDCA nanoparticles loaded with rHuTNF-α showed higher anti-tumor potency at the same dose, which might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoparticles could be an effective carrier for rHuTNF-α.

Corresponding author

Register with J-STAGE for free!