Spirocyclopropane Compounds. II. Synthesis and Biological Activities of Spiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-ones

MITSURU KAWADA; HIROSADA SUGIHARA; IWAO MIKAMI; KIYOHISA KAWAI; SEIJI KUZUNA; SHUNSAKU NOGUCHI; YASUSHI SANNO

doi:10.1248/cpb.29.1912

MITSURU KAWADA, HIROSADA SUGIHARA, IWAO MIKAMI, KIYOHISA KAWAI, SEIJI KUZUNA, SHUNSAKU NOGUCHI, YASUSHI SANNO

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Keywords: analgesic action

JOURNAL FREE ACCESS

1981 Volume 29 Issue 7 Pages 1912-1919

DOI https://doi.org/10.1248/cpb.29.1912

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Abstract

Spiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-ones with various substituents on the benzene ring and at the 1'-position were synthesized. Investigation of their biological activities revealed that significant anti-inflammatory and analgesic activities were exhibited by some compounds of this series. Their structure-activity relationships are discussed.

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