Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Chinese Crude Drug "Forsythiae Fructus." VI. The Structure and Antibacterial Activity of Suspensaside isolated from Forsythia suspensa
SANSEI NISHIBEKAZUKO OKABEHIROKI TSUKAMOTOAKIYO SAKUSHIMASUEO HISADAHISAE BABATAISUKE AKISADA
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1982 Volume 30 Issue 12 Pages 4548-4553

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Abstract

A new caffeoyl glycoside of β, 3, 4-trihydroxyphenethyl alcohol, designated as suspensaside (1), was isolated from the fruits of Forsythia suspensa VAHL (Oleaceae). The structure of 1 was established as DL-β, 3, 4-trihydroxyphenethyl-O-α-L-rhamnopyranosyl-(1→6)-4-O-caffeoyl-β-D-glucopyranoside on the basis of analysis of the carbon-13 nuclear magnetic resonance spectrum and chemical evidence. Compound 1 exhibited antibacterial activity against Staphylococcus aureus TERASHIMA. with MIC 4.1 mM (2.6 mg/ml).

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© The Pharmaceutical Society of Japan
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