MATTEUORIENATE A AND B, TWO NEW AND POTENT ALDOSE REDUCTASE INHIBITORS FROM MATTEUCCIA ORIENTALIS (HOOK.) TREV.

Shigetoshi KADOTA; Purusotam BASNET; Koji HASE; Tsuneo NAMBA

doi:10.1248/cpb.42.1712

Shigetoshi KADOTA, Purusotam BASNET, Koji HASE, Tsuneo NAMBA

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Keywords: matteuorienate A, matteuorienate B, aldose reductase, Matteuccia orientalis

JOURNAL FREE ACCESS

1994 Volume 42 Issue 8 Pages 1712-1714

DOI https://doi.org/10.1248/cpb.42.1712

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Abstract

Matteuorienate A and B, two new C-methyl flavanone derivatives, were isolated from the Matteuccia orientalis (Hook.) Trev. (Aspidiaceae), and their structures were determined by the use of spectroscopic methods including 2D-NMR (¹H-¹H COSY, ¹H-¹³C COSY and ¹H-¹³C long-range COSY) experiments and chemical methods. Both the compounds were found to be very strong inhibitors of aldose reductase among the natural products.

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