Chemical Constituents of Prangos tschimganica; Structure Elucidation and Absolute Configuration of Coumarin and Furanocoumarin Derivatives with Anti-HIV Activity

Yasuhiro SHIKISHIMA; Yoshihisa TAKAISHI; Gisho HONDA; Michiho ITO; Yoshio TAKEDA; Olimjon K. KODZHIMATOV; Ozodbek ASHURMETOV; Kuo-Hsing LEE

doi:10.1248/cpb.49.877

Regular Articles

Chemical Constituents of Prangos tschimganica; Structure Elucidation and Absolute Configuration of Coumarin and Furanocoumarin Derivatives with Anti-HIV Activity

Yasuhiro SHIKISHIMA, Yoshihisa TAKAISHI, Gisho HONDA, Michiho ITO, Yoshio TAKEDA, Olimjon K. KODZHIMATOV, Ozodbek ASHURMETOV, Kuo-Hsing LEE

Author information

Keywords: Prangos tschimganica, Umbelliferae, coumarin derivative, anti-human immunodeficiency virus(HIV) activity, optical purity

JOURNAL FREE ACCESS

2001 Volume 49 Issue 7 Pages 877-880

DOI https://doi.org/10.1248/cpb.49.877

Details

Abstract

The methanol extract of the dried aerial parts of Prangos tschimganica gave three new coumarin derivatives and 30 known coumarin derivatives. Their structures were established on the basis of chemical and spectroscopic evidence. Absolute configuration of the isolated compounds were determined by using a modified Mosher’s method. Some of the isolated compounds showed anti-HIV activity.

Corresponding author

Register with J-STAGE for free!