New Farnesane-Type Sesquiterpenes, Hedychiols A and B 8,9-Diacetate, and Inhibitors of Degranulation in RBL-2H3 Cells from the Rhizome of Hedychium coronarium

Toshio Morikawa; Hisashi Matsuda; Yasuko Sakamoto; Kazuho Ueda; Masayuki Yoshikawa

doi:10.1248/cpb.50.1045

Regular Articles

New Farnesane-Type Sesquiterpenes, Hedychiols A and B 8,9-Diacetate, and Inhibitors of Degranulation in RBL-2H3 Cells from the Rhizome of Hedychium coronarium

Toshio Morikawa, Hisashi Matsuda, Yasuko Sakamoto, Kazuho Ueda, Masayuki Yoshikawa

Author information

Keywords: hedychiol, Hedychium coronarium, degranulation inhibitor, hedychilactone A, coronarin D, Zingiberaceae

JOURNAL FREE ACCESS

2002 Volume 50 Issue 8 Pages 1045-1049

DOI https://doi.org/10.1248/cpb.50.1045

Details

Abstract

Two new farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, were isolated from the methanolic extract of the fresh rhizome of Hedychium coronarium KOEN. cultivated in Japan. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of isolated constituents on the release of β-hexosaminidase from RBL-2H3 cells were examined, and hedychilactone A and coronarin D were found to show the inhibitory activity.

Corresponding author

Register with J-STAGE for free!