Medicinal Flowers. VI. Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L.: Their Inhibitory Activities for Rat Lens Aldose Reductase

Hisashi Matsuda; Toshio Morikawa; Iwao Toguchida; Shoichi Harima; Masayuki Yoshikawa

doi:10.1248/cpb.50.972

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Medicinal Flowers. VI. Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L.: Their Inhibitory Activities for Rat Lens Aldose Reductase

Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Masayuki Yoshikawa

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Keywords: aldose reductase inhibitor, Chrysanthemum indicum, medicinal flower, (2S)-eriodictyol 7-O-β-D-glucopyranosiduronic acid, (2R)-eriodictyol 7-O-β-D-glucopyranosiduronic acid, (2S,3S)-1-phenyl-2,3-butanediol 3-O-β-D-glucopyranoside

JOURNAL FREE ACCESS

2002 Volume 50 Issue 7 Pages 972-975

DOI https://doi.org/10.1248/cpb.50.972

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Abstract

Two new flavanone glycosides, (2S)- and (2R)-eriodictyol 7-O-β-D-glucopyranosiduronic acids, and a new phenylbutanoid glycoside, (2S, 3S)-1-phenyl-2,3-butanediol 3-O-β-D-glucopyranoside, were isolated from the flowers of Chrysanthemum indicum L. cultivated in China together with eight flavonoids. The absolute stereostructures of the new compounds were determined on the basis of chemical and physicochemical evidence. Both of the new flavanone glycosides were found to show inhibitory activity for rat lens aldose reductase.

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