New ent-Kaurene-Type Diterpenoids Possessing Cytotoxicity from the New Zealand Liverwort Jungermannia Species

Fumihiro Nagashima; Wakana Kasai; Masuo Kondoh; Makiko Fujii; Yoshiteru Watanabe; John Edward Braggins; Yoshinori Asakawa

doi:10.1248/cpb.51.1189

Notes

New ent-Kaurene-Type Diterpenoids Possessing Cytotoxicity from the New Zealand Liverwort Jungermannia Species

Fumihiro Nagashima, Wakana Kasai, Masuo Kondoh, Makiko Fujii, Yoshiteru Watanabe, John Edward Braggins, Yoshinori Asakawa

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Keywords: Jungermannia species, liverwort, ent-kaurene, diterpenoid, cytotoxicity, HL-60 cell

JOURNAL FREE ACCESS

2003 Volume 51 Issue 10 Pages 1189-1192

DOI https://doi.org/10.1248/cpb.51.1189

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Abstract

Two new ent-kaurene-type and a new rearranged ent-kaurene-type diterpenoids possessing cytotoxicity against a human leukemia cell line have been isolated from the New Zealand liverwort Jungermannia species, together with previously known ent-kaurene-type diterpenoids. Their structures were established based on extensive NMR techniques.

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