A One-Step Synthesis of 2-Alkyl-5-hydroxychromones and 3-Alkoyl-2-alkyl-5-hydroxychromones

Sabrina Okombi; Julien Schmidt; Anne-Marie Mariotte; Eric Perrier; Ahcène Boumendjel

doi:10.1248/cpb.53.1460

Notes

A One-Step Synthesis of 2-Alkyl-5-hydroxychromones and 3-Alkoyl-2-alkyl-5-hydroxychromones

Sabrina Okombi, Julien Schmidt, Anne-Marie Mariotte, Eric Perrier, Ahcène Boumendjel

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Keywords: 2-substituted chromone, 2,3-disubstituted chromone, one-step synthesis

JOURNAL FREE ACCESS

2005 Volume 53 Issue 11 Pages 1460-1462

DOI https://doi.org/10.1248/cpb.53.1460

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Abstract

2-Alkyl-5-hydroxychromones (2-alkyl-5-hydroxy-4-oxo-4H-1-benzopyran) and 3-alkoyl-2-alkyl-5-hydroxychromones (3-alkoyl-2-alkyl-5-hydroxy-4-oxo-4H-1-benzopyran) were prepared in one-step and one pot reaction by condensation of 2′,6′-dihydroxyacetophenone with an alkoyl chloride in the presence of K₂CO₃.

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