Cucurbitane Glycosides from Unripe Fruits of Lo Han Kuo (Siraitia grosvenori)

Dianpeng Li; Tsuyoshi Ikeda; Nanae Matsuoka; Toshihiro Nohara; Hourui Zhang; Tatsunori Sakamoto; Gen-Ichiro Nonaka

doi:10.1248/cpb.54.1425

Notes

Cucurbitane Glycosides from Unripe Fruits of Lo Han Kuo (Siraitia grosvenori)

Dianpeng Li, Tsuyoshi Ikeda, Nanae Matsuoka, Toshihiro Nohara, Hourui Zhang, Tatsunori Sakamoto, Gen-Ichiro Nonaka

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Keywords: Siraitia grosvenori, Lo Han Kuo, Cucurbitaceae, unripe fruit, bitter principle, cucurbitane-glycoside

JOURNAL FREE ACCESS

2006 Volume 54 Issue 10 Pages 1425-1428

DOI https://doi.org/10.1248/cpb.54.1425

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Abstract

From the unripe fruits of Lo Han Kuo (Siraitia grosvenori), a Chinese medicinal plant, two new cucurbitane triterpene glycosides, 20-hydroxy-11-oxomogroside IA₁ (1) and 11-oxomogroside IIE (2), were isolated along with five known cucurbitane glycosides, 11-oxomogroside IA₁ (3), mogroside IIE (4), mogroside III (5), mogroside IVA (6), and mogroside V (7), and two flavonoid glycosides, kaempferol 7-O-α-L-rhamnopyranoside (8) and kaempferol 3,7-di-O-α-L-rhamnopyranoside (9). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods and by comparing with literature values. This paper describes the first investigation of unripe bitter Lo Han Kuo fruits.

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