Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Two Flavonoids from the Leaves of Mours alba Induce Differentiation of the Human Promyelocytic Leukemia (HL-60) Cell Line
Sun Yeou KIMJian Jun GAOHee Kyoung KANG
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2000 Volume 23 Issue 4 Pages 451-455

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Abstract

Two flavonoids, quercetin-3-O-β-D-glucopyranoside (1) and quercetin-3, 7-di-O-β-D-glucopyranoside (2), were isolated from the leaves of Mours alba (Moraceae). These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2×10-4 M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens. These flavonoids exhibited significant free radical scavenging effects on 1, 1-diphenyl-2-picyl-hydrazyl radical.

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© The Pharmaceutical Society of Japan
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