Studies on β-Lactam Antibiotics. XIV. : Synthesis and Biological Activity of the (E)-Isomer of FK027
Keywords:
antimicrobial activity
1986 Volume 34 Issue 8 Pages 3458-3464
Details
1986 Volume 34 Issue 8 Pages 3458-3464
The (E)-isomer (11) of FK027 was synthesized by two methods. The effect of the configuration of the oxime in the 7-acyl side chain of FK027 (1) on the antimicrobial activity and oral absorbability in rats was investigated. Both FK027 (1) and its (E)-isomer (11) showed appreciable oral absorbability regardless of the configuration of the oxime.
