Syntheses and Antitumor Activities of N6, N6-Dimethyladenosine Carboxylate Analogues

Tsukasa TAKAMURA; Tetsuo KATO; Eitaro ARAKAWA; Shuichi OGAWA; Yasuko SUZUMURA; Taketoshi KATO

doi:10.1248/cpb.37.2828

Syntheses and Antitumor Activities of N⁶, N⁶-Dimethyladenosine Carboxylate Analogues

Tsukasa TAKAMURA, Tetsuo KATO, Eitaro ARAKAWA, Shuichi OGAWA, Yasuko SUZUMURA, Taketoshi KATO

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Keywords: antitumor activity, L1210 leukemia, Ehrlich ascites, N⁶, N⁶-dimethyladenosine, long-chain aliphatic ester, tritylation

JOURNAL FREE ACCESS

1989 Volume 37 Issue 10 Pages 2828-2831

DOI https://doi.org/10.1248/cpb.37.2828

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Abstract

Several analogues substituted with fatty acid at the 2'-, 3'-, or 5'-position of the ribose moiety of N⁶, N⁶-dimethyladenosine were synthesized and tested for antitumor activity against cultured cells of L1210 leukemia and/or Ehrlich ascites. The cytotoxity and increase of life span obtained with congeners in the N⁶, N⁶-dimethyladenosine 3'- or 5'-substituted series were comparable to in vitro or several times better in vivo than those of the mother compound.

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