1990 Volume 38 Issue 5 Pages 1158-1164
Acid hydrolysis of unsymmetrical N1, N2-disubstituted acetamidine and formamidine was examined kinetically in aqueous dioxane solution. The reaction afforded the more basic amine and the N-acyl derivative of the less basic amine. Increasing the dioxane content in the solvent increased the reaction rate. The reaction can be rationalized in terms of specific acid-general base catalysis.