Degradation of 3-Aryl-2-hydroxyiminopropionic Acids into Arylacetonitriles Using 1, 1'-Carbonyldiimidazole or 2, 2'-Oxalyldi(o-sulfobenzimide)

Tokujiro KITAGAWA; Megumi KAWAGUCHI; Sachie INOUE; Shinji KATAYAMA

doi:10.1248/cpb.39.3030

Tokujiro KITAGAWA, Megumi KAWAGUCHI, Sachie INOUE, Shinji KATAYAMA

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Keywords: 1, 1'-carbonyldiimidazole, 2, 2'-oxalyldi (o-sulfobenzimide), arylacetonitrile, 3-aryl-2-hydroxyiminopropionic acid, dehydration, decarboxylation, degradation

JOURNAL FREE ACCESS

1991 Volume 39 Issue 11 Pages 3030-3033

DOI https://doi.org/10.1248/cpb.39.3030

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Abstract

1, 1'-Carbonyldiimidazole (1) is a useful reagent for the preparation of arylacetonitriles (9) from 3-aryl-2-hydroxyiminopropionic acids (8), and 2, 2'-oxalyldi (o-sulfobenzimide) (2) can also be used for this purpose under essentially neutral conditions.

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