NON-STEREOSPECIFIC FORMATION OF 3α, 7α, 24-TRIHYDROXY-5β-CHOLESTAN-26-OIC ACID DURING CHENODEOXYCHOLIC ACID BIOSYNTHESIS

Noriko KOBAYASHI; Chiaki HAGIWARA; Masuo MORISAKI; Masatoshi YURI; Yoshinori FUJIMOTO

doi:10.1248/cpb.42.1536

Noriko KOBAYASHI, Chiaki HAGIWARA, Masuo MORISAKI, Masatoshi YURI, Yoshinori FUJIMOTO

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Keywords: chenodeoxycholic acid, β-oxidation, bile acid, 3α, 7α-dihydroxy-5β-cholestan-26-oic acid, 3α, 7α, 24-trihydroxy-5β-cholestan-26-oic acid

JOURNAL FREE ACCESS

1994 Volume 42 Issue 7 Pages 1536-1538

DOI https://doi.org/10.1248/cpb.42.1536

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Abstract

Incubation of 3α, 7α-dihydroxy-5β-cholestan-26-oic acid and its Δ²⁴- analog with rat liver homogenate produced a mixture of C-24, 25 diastereoisomers of 3α, 7α, 24-trihydroxy-5β-cholestan-26-oic acid, a key intermediate of chenodeoxycholic acid biosynthesis.

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