LIPASE-MEDIATED ROUTE TO DIASTEREO-PURE TRANEXAMIC ACID

Takashi WATANABE; Jin HASEGAWA; Kou HIROYA; Kunio OGASAWARA

doi:10.1248/cpb.43.529

Takashi WATANABE, Jin HASEGAWA, Kou HIROYA, Kunio OGASAWARA

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Keywords: tranexamic acid, diastereomeric separation, lipase-mediated transesterification, lipase-mediated hydrolysis, antiplasmic activity

JOURNAL FREE ACCESS

1995 Volume 43 Issue 3 Pages 529-531

DOI https://doi.org/10.1248/cpb.43.529

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Abstract

Diastereomerically pure tranexamic acid has been prepared via a diastereomeric separation of a trans-/cis-mixture of 1, 4-cyclohexanedimethanol using lipase PS (Pseudomonas sp. Amino).

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