Conversion of Quassinoids for Enhancement of Inhibitory Effect against Epstein-Barr Virus Early Antigen Activation. Introduction of Lipophilic Side Chain and Esterification of Diosphenol

Sadaaki TAMURA; Narihiko FUKAMIYA; Xiao-Yang MOU; Teruo MUKAINAKA; Hrukuni TOKUDA; Hoyoku NISHINO; Kiyoshi TAGAHARA; Kazuo KOIKE; Kuo-Hsiung LEE; Masayoshi OKANO

doi:10.1248/cpb.48.876

Sadaaki TAMURA, Narihiko FUKAMIYA, Xiao-Yang MOU, Teruo MUKAINAKA, Hrukuni TOKUDA, Hoyoku NISHINO, Kiyoshi TAGAHARA, Kazuo KOIKE, Kuo-Hsiung LEE, Masayoshi OKANO

Author information

Sadaaki TAMURA
Narihiko FUKAMIYA
Xiao-Yang MOU
Teruo MUKAINAKA
Hrukuni TOKUDA
Hoyoku NISHINO
Kiyoshi TAGAHARA
Kazuo KOIKE
Kuo-Hsiung LEE
Masayoshi OKANO
Author's Organization：
Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University
Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University
Department of Biochemistry, Kyoto Prefectural University of Medicine
Department of Biochemistry, Kyoto Prefectural University of Medicine
Department of Biochemistry, Kyoto Prefectural University of Medicine
Department of Biochemistry, Kyoto Prefectural University of Medicine
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University
School of Pharmaceutical Sciences, Toho University
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina
Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University

Keywords: quassinoid conversion, lipophilic side chain, diosphenol esterification, inhibitory effect against Epstein-Barr virus early antigen activation

JOURNAL FREE ACCESS

2000 Volume 48 Issue 6 Pages 876-878

DOI https://doi.org/10.1248/cpb.48.876

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Abstract

Introduction of a senecioyl group into shinjulactones B and C, and esterification of the diosphenol moiety in brusatol and brucein A enhanced inhibitory effect against Epstein-Barr virus early antigen activation.

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