Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis

Haruka Fujimoto; Tomomi Noguchi; Hisayoshi Kobayashi; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.54.855

Regular Articles

Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis

Haruka Fujimoto, Tomomi Noguchi, Hisayoshi Kobayashi, Hiroyuki Miyachi, Yuichi Hashimoto

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Keywords: thalidomide, immunomodulatory derivative of thalidomide (IMiD), differentiation, angiogenesis, cyclooxygenase

JOURNAL FREE ACCESS

2006 Volume 54 Issue 6 Pages 855-860

DOI https://doi.org/10.1248/cpb.54.855

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Abstract

Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3, 5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on HL-60 cells and anti-angiogenic activity on human umbilical vein endothelial cells (HUVEC). AIDO-00 (7) also showed anti-angiogenic activity. NIDO-11 (8) showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation, and AIDO-30 (13) exhibited cyclooxygenase (COX)-inhibitory activity.

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