Bioactive Constituents from Chinese Natural Medicines. XXXII.  Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B4, B5, C1, and D1—D3

Toshio Morikawa; Haihui Xie; Tao Wang; Hisashi Matsuda; Masayuki Yoshikawa

doi:10.1248/cpb.56.1438

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Bioactive Constituents from Chinese Natural Medicines. XXXII. Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B₄, B₅, C₁, and D₁—D₃

Toshio Morikawa, Haihui Xie, Tao Wang, Hisashi Matsuda, Masayuki Yoshikawa

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Keywords: Sinocrassula indica, sinocrassoside, aminopeptidase N inhibitor, aldose reductase inhibitor, Crassulaceae

JOURNAL FREE ACCESS

2008 Volume 56 Issue 10 Pages 1438-1444

DOI https://doi.org/10.1248/cpb.56.1438

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Abstract

From the methanolic extract of the whole plant of Sinocrassula indica (Crassulaceae), six new flavonol glycosides, sinocrassosides B₄ (1), B₅ (2), C₁ (3), D₁ (4), D₂ (5), and D₃ (6), were isolated together with 30 compounds. The structures of 1—6 were elucidated on the basis of chemical and physicochemical evidence. In addition, several constituents were found to show inhibitory effects on aminopeptidase N and aldose reductase.

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