Macrophage Scavenger Receptors: Structure, Function and Tissue Distribution

Motohiro Takeya; Ryu-ichiro Tomokiyo; Katsunori Jinnouchi; Hisashi Sakaguchi; Sho-ichiro Hagiwara; Makoto Honda; Youichiro Wada; Hiroshi Suzuki; Tatsuhiko Kodama; Kiyoshi Takahashi

doi:10.1267/ahc.32.47

Motohiro Takeya, Ryu-ichiro Tomokiyo, Katsunori Jinnouchi, Hisashi Sakaguchi, Sho-ichiro Hagiwara, Makoto Honda, Youichiro Wada, Hiroshi Suzuki, Tatsuhiko Kodama, Kiyoshi Takahashi

Author information

Motohiro Takeya
Second Department of Pathology, Kumamoto University School of Medicine
Ryu-ichiro Tomokiyo
Second Department of Pathology, Kumamoto University School of Medicine
Katsunori Jinnouchi
Second Department of Pathology, Kumamoto University School of Medicine
Hisashi Sakaguchi
Second Department of Pathology, Kumamoto University School of Medicine
Sho-ichiro Hagiwara
Second Department of Pathology, Kumamoto University School of Medicine
Makoto Honda
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo
Youichiro Wada
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo
Hiroshi Suzuki
Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd.
Tatsuhiko Kodama
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo
Kiyoshi Takahashi
Second Department of Pathology, Kumamoto University School of Medicine

Keywords: Macrophage scavenger receptors, Knockout mice, Atherosclerosis, Infection, Monoclonal antibodies

JOURNAL FREE ACCESS

1999 Volume 32 Issue 1 Pages 47-51

DOI https://doi.org/10.1267/ahc.32.47

Details

Abstract

Macrophage scavenger receptor (MSR) is one of the major receptors of macrophages. It plays an important role in the pathological deposition of cholesterol in macrophage-derived foam cells during atherogenesis through receptor-mediated uptake of modified low density lipoproteins. MSR is also important for macrophages to recognize and eliminate pathogenic microorganisms. Targeted disruption of the MSR gene resulted in a reduction in the size of atherosclerotic lesions in atherosclerosis model mice. MSR-knockout mice were more susceptible to infection. Hepatic granuloma formation induced by a single intravenous injection of heat-killed Corynebacterium parvum was significantly delayed in MSR-knockout mice. Using MSR-knockout mice as immunization animals, five monoclonal antibodies against human MSR were successfully produced. Immunohistochemistry using these antibodies revealed a restricted distribution of MSR protein on tissue macrophages in various tissues and organs. These antibodies will provide a new approach to study the role of MSR in normal and various pathological conditions in humans.

Corresponding author

Register with J-STAGE for free!