Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
  • José M. Olmos-Martínez
    Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain
  • Helena Molina
    Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain
  • Cristina Salas
    Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain
  • José M. Olmos
    Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain
  • José L. Hernández
    Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain

Keywords

Colchicine, neuromyopathy, atorvastatin, clarithromycin

Abstract

Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy.

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    Published: 2019-03-18
    Issue: Vol 6 No 3 (view)


    How to cite:
    1.
    Olmos-Martínez JM, Molina H, Salas C, Olmos JM, Hernández JL. Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin. EJCRIM 2019;6 doi:10.12890/2019_001066.