Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Review
Thresholds for DNA-Reactive (Genotoxic) Organic Carcinogens
Gary M. Williams, Michael J. Iatropoulos, Alan M. Jeffrey
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Keywords: neoplasms, 2-acetylaminofluorene, diethylnitrosamine, DNA adducts, carcinogens, DNA damage
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2005 Volume 18 Issue 2 Pages 69-77

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Abstract

This paper reviews the evidence for thresholds for DNA-reactive carcinogens and presents dose response data for effects in rat liver of two DNA-reactive hepatocarcinogens, diethylnitrosamine and 2-acetylaminofluorene, which is consistent with thresholds.

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© 2005 The Japanese Society of Toxicologic Pathology
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