Abstract
In the aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK) promoted by chiral phosphine Lewis base: (R)-2'-diphenylphosphanyl-[1,1']binaphthalenyl-2-ol (LB1) (10 mol %), the aza-Morita-Baylis-Hillman adducts were obtained in good yields with high ee (70-94 % ee) at -30 °C in THF. The scope and limitations of this reaction have been disclosed.
Keywords: aza-Baylis-Hillman; Baylis-Hillman reaction; chiral phosphine Lewis bases; methyl vinyl ketone; N-sulfonated imines
Conference
IUPAC International Conference on Heteroatom Chemistry (ICHAC-7), International Conference on Heteroatom Chemistry, ICHAC, Heteroatom Chemistry, 7th, Shanghai, China, 2004-08-21–2004-08-25
Published Online: 2009-01-01
Published in Print: 2005-01-01
© 2013 Walter de Gruyter GmbH, Berlin/Boston
