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Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells

Fig 5

Chronic exposure of human PAC to nicotine decreases carrier-mediated [3H] thiamin uptake.

Human PAC were exposed to nicotine (0.5 μM, 48 h) and carrier-mediated uptake of 3H-thiamin was determined as described under “Materials and Methods”. Data represents the mean ± SE of at least three separate uptake determinations.*P < 0.01.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0143575.g005