Abstract
The effects of d-glucose, d-mannose, d-galactose, d-glyceraldehyde, pyruvate, l-lactate, 2-ketoisocaproate, l-leucine, and/or l-glutamine on the ATP and ADP content of rat isolated pancreatic islets were reevaluated in order to compare changes evoked by these nutrient secretagogues in the islet ATP content and ATP/ADP ratio to their effects upon insulin release. Although being compatible with the fuel concept for nutrient-stimulated insulin secretion, the results of this study also argue against the monolithic view that the adenine nucleotide pattern in islet cells represents the sole coupling factor between metabolic and more distal events in the process of nutrient-stimulated insulin release.
Similar content being viewed by others
References
Malaisse, W. J., Sener, A., Herchuelz, A., and Hutton, J. C. (1979). Metabolism 28, 373–386.
Malaisse, W. J. (1983). Diab. Metab. 9, 313–320.
Malaisse, W. J., Malaisse-Lagae, F., and Sener, A. (1984). Experientia 40, 1035–1043.
Henquin, J.-C., Debuyser, A., Drews, G., and Plant, T. D. (1992) In: Nutrient regulation of insulin, secretion. Flatt, P. R. (ed.). Portland Press: London, pp. 173–191.
Howell, S. L. and Tyhurst, M. (1984). Experimentia 40, 1098–1105.
Henquin, J.-C., Detimary, P., Gembal, M. et al. (1994) In: Journées de diabétologie de l'hôtel-dieu. Flammarion: Paris. pp. 21–32.
Carpinelli, A. R., and Malaisse, W. J. (1981). J. Physiol. (London) 315, 143–156.
Best, L. (2002). Diab. Metab. 28, 3S18–3S24.
Malaisse, W. J., Zhang, Y., Louchami, K., and Jijakli, H. (2004). Endocrine 25, 23–25.
Oguzhan, B., Agascioglu, E., Giroix, M.-H., et al. (2005). Abstracts 41st International Diabetes Congress, Antalya, Turkey.
Giroix, M.-H., Malaisse-Lagae, F., Sener, A., and Malaisse, W. J. (1985). Mol. Cell. Biochem. 66, 61–64.
Sener, A., Kawazu, S., Hutton, J. C., et al. (1978). Biochem. J. 176, 217–232.
Malaisse, W. J., Kawazu, S., Herchuelz, A., et al. (1979). Arch. Biochem. Biophys. 194, 49–62.
Malaisse, W. J., Sener, A., Carpinelli, A. R., et al. (1980). Mol. Cell. Biochem. 33, 157–159.
Sener, A. and Malaisse, W. J. (1980). Mol. Cell Endocrinol. 20, 171–189.
Hutton, J. C., Sener, A., and Malaisse, W. J. (1979). Biochem. J. 184, 303–311.
Malaisse, W. J., Hutton, J. C., Carpinelli, A. R., et al. (1980). Diabetes 29, 433–437.
Malaisse, W. J., Sener, A., Levy, J., and Herchuelz, A. (1976). Acta Diabet. Lat. 13, 202–215.
Hutton, J. C., Sener, A., Herchuelz, A., et al. (1980). Endocrinology 106, 203–219.
Anjaneyulu, R., Anjaneyulu, K., Carpinelli, A. R. et al. (1981). Arch. Biochem. Biophys. 212, 54–62.
Malaisse, W. J., Sener, A., Malaisse-Lagae, F., et al. (1982). J. Biol. Chem. 257, 8731–8737.
Hutton, J. C., Sener, A., and Malaisse, W. J. (1980). J. Biol. Chem. 255, 7340–7346.
Sener, A. and Malaisse, W. J. (1980). Diab. Metab. 6, 97–101.
Malaisse-Lagae, F. and Malaisse, W. J. (1984). In: Methods in diabetes research. Larner, J. and Pohl, S. L. (eds.). Wiley: New York, Vol. 1, pp. 147–152.
Malaisse, W. J., Maggetto, C., Leclercq-Meyer, V., and Sener, A. (1993). J. Clin. Invest. 91, 432–436.
Stanley, P. E. and Williams, S. G. (1969). Anal. Biochem. 29, 381–382.
Gallez, F., Fadel, M., Scruel, O., et al. (2000). Cell Biochem. Funct. 18, 103–108.
Scruel, O., Sener, A., and Malaisse, W. J. (1999). Mol. Cell. Biochem. 197, 209–216.
Sener, A. and Malaisse, W. J. (1996). Biochim. Biophys. Acta 1312, 73–78.
Malaisse, W. J., Herchuelz, A., Levy, J., et al. (1976). Mol. Cell. Endocrinol. 4, 1–12.
Sener, A., Somers, G., Devis, G., and Malaisse, W. J. (1981). Diabetologia 21, 135–142.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Agascioglu, E., Giroix, MH., Malaisse, W.J. et al. Adenine nucleotide pattern in rat pancreatic islets exposed to nutrient secretagogues. Endocr 29, 325–329 (2006). https://doi.org/10.1385/ENDO:29:2:325
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/ENDO:29:2:325