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The function role of GATA-3 in Th1 and Th2 differentiation

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Abstract

GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6. GATA-3 regulates Th2 cytokine expression notonly at the transcription level, such asdirectly binding to the promoters of the IL-5 and IL-13 gene, but also by the involvement in the remodeling of the chromatin structure and opening the IL-4 locus. As a master control, GATA-3 stabilizes the Th2 phenotype by two methods. First, GATA-3 shuts down Th1 development through the repression the IL-12 receptor β2-chain expression. Second, GATA-3 augments its own expression by a positive feedback autoregulation. In this article, we review the recent study of the function of GATA-3 in Th1 and Th2 differentiation.

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  1. Wenjun Ouyang

    Present address: Department of Immunology, Genentech, Inc., 1 DNA Way, 94080, South San Francisco, CA

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  1. Department of Pathology, Washington University School of Medicine, St. Louis, MO

    Meixia Zhou

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Zhou, M., Ouyang, W. The function role of GATA-3 in Th1 and Th2 differentiation. Immunol Res 28, 25–37 (2003). https://doi.org/10.1385/IR:28:1:25

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