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Are we really on the right TRAIL?

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References

  1. Bouillet P, Purton JF, Godfrey DI, et al.: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002;415:922–926.

    Article  PubMed  CAS  Google Scholar 

  2. Rathmell JC, Lindsten T, Zong WX, et al.: Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 2002;3:932–939.

    Article  PubMed  CAS  Google Scholar 

  3. Calnan BJ, Szychowski S, Chan FK, et al.: A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 1995;3:273–282.

    Article  PubMed  CAS  Google Scholar 

  4. Mountz JD, Zhou T, Eldridge J, et al.: Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4 −CD8−B220+ T cells in lpr/lpr mice. J Exp Med 190;172:1805–1817.

  5. Sprent J, Kishimoto H: The thymus and negative selection. Immunol Rev 2002;185:126–135.

    Article  PubMed  CAS  Google Scholar 

  6. Page DM, Roberts EM, Peschon JJ, Hedrick SM: TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol 1998;160:120–133.

    PubMed  CAS  Google Scholar 

  7. Wang EC, Thern A, Denzel A, et al.: DR3 regulates negative selection during thymocyte development. Mol Cell Biol 2001;21:3451–3461.

    Article  PubMed  CAS  Google Scholar 

  8. Wang J, Chun T, Lo JC et al.: The critical role of LIGHT, a TNF family member, in T cell development. J Immunol 2001;167:5099–5105.

    PubMed  CAS  Google Scholar 

  9. DeYoung AL, Duramad O, Winoto A: The TNF receptor family member CD30 is not essential for negative selection. J Immunol 2000;165:6170–6173.

    PubMed  CAS  Google Scholar 

  10. Lamhamedi-Cherradi S-E, Zheng SJ, Maguschak KA, et al.: Defective thymocyte apoptosis and accelerated autoimmune disease in TRAIL-/- mice. Nat Immunol 2003;4(3):255–260.

    Article  PubMed  CAS  Google Scholar 

  11. Zheng S-J, Chen YH: TRAIL, Bim, and thymic negative selection. Immunol Res 2003;28(3):295–301.

    Article  PubMed  CAS  Google Scholar 

  12. Newton K, Harris AW, Bath ML, et al.: A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 1998;17:706–718.

    Article  PubMed  CAS  Google Scholar 

  13. Smith KG, Strasser A, Vaux DL: CrmA expression in T-lymphocytes of transgenic mice inhibits CD95 (Fas/Apo-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease. EMBO J 1996;15:5167–5176.

    PubMed  CAS  Google Scholar 

  14. Simon AK, Williams O, Mongkolsapaya J, et al.: Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: sensitivity of human thymocytes. Proc Natl Acad Sci USA 2001;98(9):5158–5163.

    Article  PubMed  CAS  Google Scholar 

  15. Cretney E, Uldrich AP, Berzins SP, et al.: Normal thymocyte negative selection in TRAIL-deficient mice. J Exp Med 2003;198(3):491–496.

    Article  PubMed  CAS  Google Scholar 

  16. Cretney E, Takeda K, Yagita H, et al.: Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 2002;168:1356–1361.

    PubMed  CAS  Google Scholar 

  17. Woodland DL, Happ MP, Gollob KJ, Palmer E: An endogenous retrovirus mediating deletion of α β T cells? Nature 1991;349:529–530.

    Article  PubMed  CAS  Google Scholar 

  18. Tomonari K, Fairchild S, Rosenwasser OA: Influence of viral superantigens on Vβ- and Vα-specific positive and negative selection. Immunol Rev 1993;131: 131–168.

    Article  PubMed  CAS  Google Scholar 

  19. Hugo P, Boyd RL, Waanders GA, et al.: Timing of deletion of autoreactive V beta 6+ cells and down-modulation of either CD4 or CD8 on phenotypically distinct CD4+8+ subsets of thymocytes expressing intermediate or high levels of T cell receptor. Int Immunol 1991; 3:265–272.

    Article  PubMed  CAS  Google Scholar 

  20. Guidos CJ, Danska JS, Fathman CG, Weissman IL. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J Exp Med 1990;172: 835–845.

    Article  PubMed  CAS  Google Scholar 

  21. Anderson MS, Venanzi ES, Klein L, et al.: Projection of an immunological self shadow within the thymus by the aire protein. Science 2002;298:1395–1401.

    Article  PubMed  CAS  Google Scholar 

  22. Liston A, Lesage S, Wilson J, et al.: Aire regulates negative selection of organ-specific T cells Nat Immunol 2003;4:350–354.

    Article  PubMed  CAS  Google Scholar 

  23. Nagamine K, Peterson P, Scott HS, et al.: Positional cloning of the APECED gene. Nat Genet 1997; 17:393–398.

    Article  PubMed  CAS  Google Scholar 

  24. Hilliard B, Wilmen A, Seidel C, et al.: Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis. J Immunol 2001;166: 1314–1319.

    PubMed  CAS  Google Scholar 

  25. Song K, Chen Y, Goke R, et al.: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med 2000;191:1095–1104.

    Article  PubMed  CAS  Google Scholar 

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Author notes

  1. Mark J. Smyth

    Present address: Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, 8006, A'Beckett St, Australia

Authors and Affiliations

  1. Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, 8006, A'Beckett St, Australia

    Erika Cretney

  2. Department of Microbiology and Immunology, University of Melbourne, 3010, Parkville, Australia

    Adam P. Uldrich, Stuart P. Berzins & Dale I. Godfrey

  3. Department of Pathology and Immunology, Monash University Medical School, 3181, Prahran, Australia

    Adam P. Uldrich

  4. The Walter and Eliza Hall Institute of Medical Research, Royal Pde, 3050, Parkville, Australia

    Andreas Strasser

Authors
  1. Erika Cretney
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  2. Adam P. Uldrich
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  3. Stuart P. Berzins
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  4. Andreas Strasser
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  5. Dale I. Godfrey
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  6. Mark J. Smyth
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Cretney, E., Uldrich, A.P., Berzins, S.P. et al. Are we really on the right TRAIL?. Immunol Res 31, 161–164 (2005). https://doi.org/10.1385/IR:31:2:161

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