Immunochemical epidermal growth factor detection in oncopathology

Piven N.V., Burakovski A.I., Tsishkevich M.N., Karpenka T.A., Yastrebova H.A.

Institute of Bioorganic Chemistry of National Academy of Sciences, Minsk, Belarus

This review provides information on the possibilities of immunochemical methods(ELISA and immunochromatographic variants) in determination of quantitative concentration of the human epidermal growth factor – a clinical, diagnostic, pathogenetic and prognostic marker of oncopathology associated with its overexpression. The general information on the structure of epidermal growth factor and its receptors and the mechanism of their interaction in the process of phosphorylation of proteins was elucidated.