Phenotypes of immune status in children with recurrent respiratory infections

Povorova O.V., Titova N.D.

A.A. Kuleshov State University, Mogilev, Republic of Belarus
Belorussian Medical Academy of Postgraduate Education, Minsk

We have observed 98 children and evaluated certain laboratory parameters, including cell counts of peripheral blood, the phagocytic activity of neutrophils, the concentration of the C3 and the C4 components of the complement, immunoglobulins (IgM, IgG, IgA, IgE) and circulating immune complexes of the serum. Leukocyte markers of CD3+, CD3+CD4+, CD3+CD8+, CD3-CD19+, CD3-CD56+, CD3+CD56+, CD3+CD25+, CD3+HLA-DR were determined by flow cytometry. In the group with reccurent respiratory infections, abnormalities of the humoral aspect of immunity were determined in 53.1% of children, with depressed IgA levels being present in 37.76% and a decrease in IgG – in 13.27%, IgE hyperproduction - in 11% (p <0,05). We have identified the main phenotypes of the immune status in children with reccurent respiratory infections – allergic – in 14.3%, immunodeficient – in 27.6%, infectious - in 6.1%, infectious-allergic – in 6.1% of children. Decrease in the level of B-lymphocytes and T-helper lymphocytes was found with a frequency of 16.39% each.
17.72 and 29.1% of children, respectively, had decreased indicators of the phagocytic index and phagocytic number, the C3 complement component levels were reduced in 8.75% of children, and 8.2% of children had a lower counts of NK cells (CD3-CD16 + CD56 +).