Polymorphism of DsbA-L Gene Associates with Insulin Secretion and Body Fat Distribution in Chinese Population

Fei GAO; Qichen FANG; Rong ZHANG; Junxi LU; Huijuan LU; Chen WANG; Xiaojing MA; Jing XU; Weiping JIA; Kunsan XIANG

doi:10.1507/endocrj.K08E-322

ORIGINALS

Polymorphism of DsbA-L Gene Associates with Insulin Secretion and Body Fat Distribution in Chinese Population

Fei GAO, Qichen FANG, Rong ZHANG, Junxi LU, Huijuan LU, Chen WANG, Xiaojing MA, Jing XU, Weiping JIA, Kunsan XIANG

Author information

Fei GAO
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Qichen FANG
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Rong ZHANG
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Junxi LU
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Huijuan LU
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Chen WANG
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Xiaojing MA
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Jing XU
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Weiping JIA
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes
Kunsan XIANG
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes

Keywords: Disulfide-bond-A oxidoreductase-like protein (DsbA-L), single nucleotide polymorphism (SNP), insulin secretion, type 2 diabetes (T2DM)

JOURNAL FREE ACCESS

2009 Volume 56 Issue 3 Pages 487-494

DOI https://doi.org/10.1507/endocrj.K08E-322

View "Advance Publication" version (February 19, 2009).

Details

Abstract

Disulfide-bond-A oxidoreductase-like protein (DsbA-L) has been suggested to take part in the disulfide bond formation progress of proteins, including insulin and adiponectin. Recent study has demonstrated that expression of DsbA-L was decreased in obese mice and human subject, indicating that DsbA-L might be a potential target for treatment of metabolic diseases. We investigated the association of SNP-1308G/T (rs1917760) of DsbA-L gene with metabolic diseases. 589 normal glucose tolerance (NGT) subjects and 556 type 2 diabetes (T2DM) subjects were recruited. Each group was divided into normal weight (NW) (BMI‹24 kg/m²) subgroup and overweight/obesity (OW/OB) (BMI≥24 kg/ m²) subgroup. Genotype distributions and allele frequencies of SNP (-1308G/T) in DsbA-L gene were not associated with T2DM and obesity. However, it was observed that T allele carriers had better insulin secretion function compared with non-T allele carriers in NGT-NW group, not only the first phase insulin secretion (P=0.007) but also the second phase insulin secretion (P=0.031). Multiple linear regression analysis revealed that SNP-1308G/T polymorphism (rs1917760) was independently correlated with both first and second phase insulin secretion in NGT-NW group (R²=0.055, P=0.007; R²=0.029, P=0.041). Otherwise, T carriers had more visceral fat than non-T carriers (P=0.020) in NGT-OW/OB group. In conclusion, the SNP-1308G/T (rs1917760) genotypes of DsbA-L gene might participate in insulin secretion and body fat distribution. It is possible that polymorphisms of DsbA-L gene associated with metabolic diseases.

Corresponding author

Register with J-STAGE for free!