In vivo Clastogenicity Assessment of the Austroplenckia populnea (Celastraceae) Leaves Extract using Micronucleus and Chromosome Aberration Assay

Gustavo de Carvalho Pugliesi; Sérgio Faloni de Andrade; Jairo Kenupp Bastos; Edson Luis Maistro

doi:10.1508/cytologia.72.1

In vivo Clastogenicity Assessment of the Austroplenckia populnea (Celastraceae) Leaves Extract using Micronucleus and Chromosome Aberration Assay

Gustavo de Carvalho Pugliesi, Sérgio Faloni de Andrade, Jairo Kenupp Bastos, Edson Luis Maistro

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Keywords: Austroplenckia populnea, Celastraceae, Micronucleus test, Chromosome aberrations

JOURNAL OPEN ACCESS

2007 Volume 72 Issue 1 Pages 1-6

DOI https://doi.org/10.1508/cytologia.72.1

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Abstract

The clastogenic effect of the A. populnea leaves extract was tested in vivo on bone marrow cells of Wistar rats by evaluating the induction of chromosome aberrations and micronuclei induction on polychromatic erythrocytes. The extract was administered by gavage at doses of 300, 600 and 900 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment. Under the conditions used, A. populnea leaves extract did not induce decrease in mitotic index and did not induce a statistically significant increase in the mean number of micronucleated polychromatic erythrocytes or chromosome aberrations in the bone marrow cells of Wistar rats.

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