Abstract
Objectives
This study aimed to explore the protective mechanism of caffeic acid (CAA) and chlorogenic acid (CHA) on cyclosporine (CSA) induced hypertensive rats.
Methods
Effect of CAA and CHA on diastolic blood pressure (DBP), mean arterial pressure (MAP), angiotensin-converting enzyme (ACE), e-nucleotide triphosphate dephosphorylase (e-NTPDase), 5′ nucleotidase and adenosine deaminase (ADA) activity in CSA-induced hypertensive rats were determined.
Results
CAA and CHA administration stabilized hypertensive effect caused by CSA administration. Also, altered activity of ACE (lung), e-NTPDase, 5′ nucleotidase, ADA as well as elevated malondiadehyde (MDA) level was restored in all the treated hypertensive rats in comparison with the untreated hypertensive rats.
Conclusion
Hence, these observed results could underlie some of the mechanisms through which CAA and CHA could offer antihypertensive effect.
Research funding: None declared.
Author contributions: Ganiyu Oboh designed the research work, proof read the manuscript and provided technical supports. Odunayo M Agunloye co-ordinated the laboratory works, performed some bioassays, wrote the manuscript and provides technical supports. Gbemisola T Bello carried out the set out experiments details and data analysis. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Research involving animals complied with all relevant National regulations and Institutional policies (Federal University of Technology, Akure Research Policy) for the care and use of animals and guidelines for animal protection and welfare were followed strictly (NIH Publications No. 8023, revised 1978).
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