Abstract
Mannich reaction of the title compound 1 with morpholine, piperidine or piperazine gave the keto-bases 2-4, respectively. Whereas, such reaction with primary amines afforded the quinazolinones 5 and 6. Compound 1 reacts with isonicotinic acid hydrazide and formalin to give 7. Schmidt reaction of 4 and 5a gave 8 and 9, respectively. Reduction of the latter afforded the 9H-pyrimido[5,4-ḇ]azepine ring system 10. The reaction of 1 with formalin was investigated.
Keywords: Mannich Bases of Enaminones; Octahydro-9H-pyrimido[5,4-ḇ]-azepines; Tetrahydro-4H-[3,1]benzoxazin-5(6H)-one; Nitrogen Heterocycles
Received: 1986-8-18
Revised: 1987-10-26
Published Online: 2014-6-2
Published in Print: 1988-4-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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