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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Trichosetin, a Novel Tetramic Acid Antibiotic Produced in Dual Culture of Trichoderma harzianum and Catharanthus roseus Callus

  • Eufrocinio C. Marfori , Shin’ichiro Kajiyama , Ei-ichiro Fukusaki and Akio Kobayashi EMAIL logo

The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite equisetin. This compound however, was not produced in the individual culture of T. harzianum or C. roseus callus.

Received: 2002-1-11
Published Online: 2014-6-2
Published in Print: 2002-6-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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