Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

Anthonia F. Afolayan; John J. Bolton; Carmen A. Lategan; Peter J. Smith; Denzil R. Beukes

doi:10.1515/znc-2008-11-1211

Open Access Published by De Gruyter June 2, 2014

Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

Anthonia F. Afolayan , John J. Bolton , Carmen A. Lategan , Peter J. Smith and Denzil R. Beukes

From the journal Zeitschrift für Naturforschung C

https://doi.org/10.1515/znc-2008-11-1211

Abstract

In the course of our search for antimalarial leads from marine algae, four metabolites, sargaquinoic acid, sargahydroquinoic acid, sargaquinal and fucoxanthin, were isolated from the South African alga Sargassum heterophyllum. Fucoxanthin and sargaquinal showed good antiplasmodial activity toward a chloroquine-sensitive strain (D10) of Plasmodium falciparum (IC₅₀ 1.5 and 2.0 μm, respectively), while sargaquinoic acid and sargahydroquinoic acid were only moderately active (IC₅₀ 12.0 and 15.2 μm, respectively).

Keywords: Antiplasmodial Activity; Fucoxanthin; Sargaquinal

Received: 2008-7-16

Published Online: 2014-6-2

Published in Print: 2008-12-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

Abstract

Journal and Issue

Articles in the same Issue